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Perioperative Medicine January 2013

Helium Induces Preconditioning in Human Endothelium In Vivo

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Kirsten F. Smit, M.D.; Gezina T. M. L. Oei, M.D., B.Sc., M.Sc.; Daniel Brevoord, M.D.; Erik S. Stroes, M.D., Ph.D.; Rienk Nieuwland, Ph.D.; Wolfgang S. Schlack, M.D., D.E.A.A.; Markus W. Hollmann, M.D., Ph.D., D.E.A.A.; Nina C. Weber, Ph.D.; Benedikt Preckel, M.D., M.A., D.E.A.A.
TOPICS: endothelium, helium, forearm, cell-derived microparticles
Anesthesiology. 2013; 118(1):95-104. doi: 10.1097/ALN.0b013e3182751300

Perioperative Medicine December 2010

Sevoflurane-induced Preconditioning: Impact of Protocol and Aprotinin Administration on Infarct Size and Endothelial Nitric-Oxide Synthase Phosphorylation in the Rat Heart In Vivo

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Jan Fräßdorf, M.D., D.E.S.A.; Ragnar Huhn, M.D., Ph.D.; Nina C. Weber, Ph.D.; Dirk Ebel, M.D.; Nadja Wingert, M.D.; Benedikt Preckel, M.D., M.A., D.E.A.A.; Octavian Toma, M.D., D.E.S.A.; Wolfgang Schlack, M.D., D.E.A.A.; Markus W. Hollmann, M.D., Ph.D., D.E.A.A.
TOPICS: aprotinin, ischemia, endothelium, infarction, ng-nitroarginine methyl ester, nitric oxide synthase, phosphorylation, heart, pimagedine, sevoflurane
Anesthesiology. 2010; 113(6):1289-1298. doi: 10.1097/ALN.0b013e3181f97fec

Perioperative Medicine December 2010

Hypoxia Induces Late Preconditioning in the Rat Heart In Vivo

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Marc M. Berger, M.D.; Ragnar Huhn, M.D., Ph.D.; Gezina T. Oei, B.Sc., M.Sc.; André Heinen, M.D., Ph.D.; Andreas Winzer, M.D.; Inge Bauer, Ph.D.; Benedikt Preckel, M.D., M.A., D.E.A.A.; Nina C. Weber, Ph.D.; Wolfgang Schlack, M.D., D.E.A.A.; Markus W. Hollmann, M.D., Ph.D., D.E.A.A.
TOPICS: hypoxia, heart
Anesthesiology. 2010; 113(6):1351-1360. doi: 10.1097/ALN.0b013e3181fce7ea

Perioperative Medicine November 2008

Helium-induced Preconditioning in Young and Old Rat Heart: Impact of Mitochondrial Ca2+-sensitive Potassium Channel Activation

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Andre Heinen, M.D.; Ragnar Huhn, M.D.; Kirsten M. A. Smeele, M.Sc.; Coert J. Zuurbier, Ph.D.; Wolfgang Schlack, M.D., D.E.A.A.; Benedikt Preckel, M.D., M.A., D.E.A.A.; Nina C. Weber, Ph.D.; Markus W. Hollmann, M.D., Ph.D., D.E.A.A.
TOPICS: western blotting, mitochondria, helium, infarction, potassium channel, heart, calcium ions
Anesthesiology. 2008; 109(5):830-836. doi: 10.1097/ALN.0b013e3181895aa0

Clinical Science February 2008

Intermitted Pharmacologic Pretreatment by Xenon, Isoflurane, Nitrous Oxide, and the Opioid Morphine Prevents Tumor Necrosis Factor α–induced Adhesion Molecule Expression in Human Umbilical Vein Endothelial Cells

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Nina C. Weber, Ph.D.; Jennis Kandler, Cand.Med.; Wolfgang Schlack, M.D., D.E.A.A.; Yvonne Grueber, M.T.A.; Jan Fräßdorf, M.D.; Benedikt Preckel, M.D., M.A., D.E.A.A.
TOPICS: tumor necrosis factors, morphine, cell adhesion molecules, endothelial cells, opioid analgesics, intercellular adhesion molecule 1, isoflurane, nitrous oxide, umbilical vein, xenon, pharmacology, opioids
Anesthesiology. 2008; 108(2):199-207. doi: 10.1097/01.anes.0000299441.32091.ed

Correspondence September 2006

Nitrous Oxide and Preconditioning

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Nina C. Weber, Ph.D.; Benedikt Preckel, M.D., D.E.A.A.; Wolfgang Schlack, M.D., D.E.A.A.

Anesthesiology. 2006; 105(3):631-631. doi:

Review Article July 2006

Molecular Mechanisms Transducing the Anesthetic, Analgesic, and Organ-protective Actions of Xenon

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Benedikt Preckel, M.D., D.E.A.A.; Nina C. Weber, Ph.D.; Robert D. Sanders, B.Sc., M.B., B.S.; Mervyn Maze, M.B., Ch.B., F.R.C.P., F.R.C.A., F.Med.Sci.; Wolfgang Schlack, M.D., D.E.A.A.
TOPICS: analgesics, xenon
Anesthesiology. 2006; 105(1):187-197. doi:

LABORATORY INVESTIGATIONS December 2005

Effects of Nitrous Oxide on the Rat Heart In Vivo : Another Inhalational Anesthetic That Preconditions the Heart?

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Nina C. Weber, Ph.D.; Octavian Toma, M.D.; Saqib Awan, Cand.med.; Jan FrAMPERSANDNUMBERSIGNx000E4;AMPERSANDNUMBERSIGNx000DF;dorf, M.D.; Benedikt Preckel, M.D., D.E.A.A.; Wolfgang Schlack, M.D., D.E.A.A.
TOPICS: anesthetics, inhalation, infarction, isoflurane, nitrous oxide, phosphorylation, translocation (genetics), heart
Anesthesiology. 2005; 103(6):1174-1182. doi: 0000542-200512000-00011

Meeting Abstracts December 2004

Desflurane Preconditioning Induces Time-dependent Activation of Protein Kinase C Epsilon and Extracellular Signal-regulated Kinase 1 and 2 in the Rat Heart In Vivo

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Octavian Toma, M.D.; Nina C. Weber, Ph.D.; Jessica I. Wolter, M.D.; Detlef Obal, M.D.; Benedikt Preckel, M.D.; Wolfgang Schlack, M.D.

Anesthesiology. 2004; 101(6):1372-1380. doi:

Meeting Abstracts March 2004

Role of Tyrosine Kinase in Desflurane-induced Preconditioning

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Dirk Ebel, M.D.; Jost Müllenheim, M.D., D.E.A.A.; Hendrik Südkamp, Cand. Med.; Thomas Bohlen, Cand. Med.; Jan Ferrari, Cand. Med.; Ragnar Huhn, Cand. Med.; Benedikt Preckel, M.D., D.E.A.A.; Wolfgang Schlack, M.D., D.E.A.A.

Anesthesiology. 2004; 100(3):555-561. doi:

Pain Medicine September 2003

Sevoflurane Confers Additional Cardioprotection after Ischemic Late Preconditioning in Rabbits

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Jost Müllenheim, M.D., D.E.A.A.; Dirk Ebel, M.D.; Mirco Bauer; Florian Otto; André Heinen; Jan Frässdorf, M.D.; Benedikt Preckel, M.D., D.E.A.A.; Wolfgang Schlack, M.D., D.E.A.A.

Anesthesiology. 2003; 99(3):624-631. doi:

Correspondence January 2003

Myocardial Ischemic Preconditioning Decreases Postischemic Oxygen Free Radical Production

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Jost Müllenheim, M.D., D.E.A.A.; Wolfgang Schlack, M.D., D.E.A.A.

Anesthesiology. 2003; 98(1):282-282. doi: 0000542-200301000-00050

Pain Medicine April 2002

Isoflurane Preconditions Myocardium against Infarction via Release of Free Radicals

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Jost Müllenheim, M.D.; Dirk Ebel, M.D.; Jan Fräβdorf, M.D.; Benedikt Preckel, M.D., D.E.A.A.; Volker Thämer, M.D.; Wolfgang Schlack, M.D., D.E.A.A.

Anesthesiology. 2002; 96(4):934-940. doi:

Pain Medicine April 2001

Effects of Ketamine and Its Isomers on Ischemic Preconditioning in the Isolated Rat Heart

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Andrei Molojavyi, M.D.; Benedikt Preckel, M.D., D.E.A.A.; Thomas Comfère; Jost Müllenheim, M.D.; Volker Thämer, M.D., Ph.D.; Wolfgang Schlack, M.D., Ph.D., D.E.A.A.

Anesthesiology. 2001; 94(4):623-629. doi:

Pain Medicine April 2001

Ketamine, but Not S (+)-ketamine, Blocks Ischemic Preconditioning in Rabbit Hearts In Vivo

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Jost Müllenheim, M.D.; Jan Fräßdorf, M.D.; Benedikt Preckel, M.D., D.E.A.A.; Volker Thämer, M.D., Ph.D.; Wolfgang Schlack, M.D., Ph.D., D.E.A.A.

Anesthesiology. 2001; 94(4):630-636. doi:

Correspondence March 2001

Mask Tolerance and Preoxygenation: A Problem for Anesthesiologists but Not for Patients

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Wolfgang Schlack, M.D., Ph.D., D.E.A.A.; Zoe Heck, M.D.; Christel Lorenz, M.D., D.E.A.A.

Anesthesiology. 2001; 94(3):546-546. doi:

Meeting Abstracts September 2000

Room D, 10/16/2000 2: 00 PM - 4: 00 PM (PS) Lidocaine Reduces Ischemic Injury but Not Reperfusion Injury in the Isolated Rat Heart : A-629

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Dirk Ebel, MD; Peter Lipfert, MD, PhD; Benedikt Preckel, MD; Volker Thamer, MD, PhD; Wolfgang Schlack, MD, PhD

Anesthesiology. 2000; 93(3A):A-629. doi:

Pain Medicine September 2000

Room D, 10/16/2000 2: 00 PM - 4: 00 PM (PS) Blockade of Ischemic Preconditioning by Ketamine is Enantiomer Specific In Vivo : A-641

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Jost Mullenheim, MD; Jan Frassdorf, MD; Benedikt Preckel, MD; Volker Thamer, MD; Wolfgang Schlack, MD

Anesthesiology. 2000; 93(3A):A-641. doi:

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Helium Induces Preconditioning in Human Endothelium In Vivo

Sevoflurane-induced Preconditioning: Impact of Protocol and Aprotinin Administration on Infarct Size and Endothelial Nitric-Oxide Synthase Phosphorylation in the Rat Heart In Vivo

Hypoxia Induces Late Preconditioning in the Rat Heart In Vivo

Helium-induced Preconditioning in Young and Old Rat Heart: Impact of Mitochondrial Ca2+-sensitive Potassium Channel Activation

Intermitted Pharmacologic Pretreatment by Xenon, Isoflurane, Nitrous Oxide, and the Opioid Morphine Prevents Tumor Necrosis Factor α–induced Adhesion Molecule Expression in Human Umbilical Vein Endothelial Cells

Nitrous Oxide and Preconditioning

Molecular Mechanisms Transducing the Anesthetic, Analgesic, and Organ-protective Actions of Xenon

Effects of Nitrous Oxide on the Rat Heart In Vivo : Another Inhalational Anesthetic That Preconditions the Heart?

Desflurane Preconditioning Induces Time-dependent Activation of Protein Kinase C Epsilon and Extracellular Signal-regulated Kinase 1 and 2 in the Rat Heart In Vivo

Role of Tyrosine Kinase in Desflurane-induced Preconditioning

Sevoflurane Confers Additional Cardioprotection after Ischemic Late Preconditioning in Rabbits

Myocardial Ischemic Preconditioning Decreases Postischemic Oxygen Free Radical Production

Isoflurane Preconditions Myocardium against Infarction via Release of Free Radicals

Effects of Ketamine and Its Isomers on Ischemic Preconditioning in the Isolated Rat Heart

Ketamine, but Not S (+)-ketamine, Blocks Ischemic Preconditioning in Rabbit Hearts In Vivo

Mask Tolerance and Preoxygenation: A Problem for Anesthesiologists but Not for Patients

Room D, 10/16/2000 2: 00 PM - 4: 00 PM (PS) Lidocaine Reduces Ischemic Injury but Not Reperfusion Injury in the Isolated Rat Heart : A-629

Room D, 10/16/2000 2: 00 PM - 4: 00 PM (PS) Blockade of Ischemic Preconditioning by Ketamine is Enantiomer Specific In Vivo : A-641

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