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Perioperative Medicine January 2019

Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review

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Marilyn Green Larach, M.D., F.A.A.P.; Thomas T. Klumpner, M.D.; Barbara W. Brandom, M.D.; Michelle T. Vaughn, M.P.H.; Kumar G. Belani, M.B.B.S., M.S., F.A.A.P.; Andrew Herlich, D.M.D., M.D., F.A.A.P., F.A.S.A.; Tae W. Kim, M.D., M.E.H.P.; Janine Limoncelli, M.D.; Sheila Riazi, M.Sc., M.D., FRCPC; Erica L. Sivak, M.D.; John Capacchione, M.D.; Darlene Mashman, M.D.; Sachin Kheterpal, M.D., M.B.A.; on behalf of the Multicenter Perioperative Outcomes Group ; Fabian Kooij, M.D.; Janet Wilczak, M.D.; Roy Soto, M.D.; Joshua Berris, D.O.; Zachary Price, M.D.; Steven Lins, M.D.; Peter Coles, M.D.; John M. Harris, M.D.; Kenneth C. Cummings, III, M.D., M.S.; Mitchell F. Berman, M.D.; Masakatsu Nanamori, M.D.; Bruce T. Adelman, M.D.; Christopher Wedeven, M.D.; John LaGorio, M.D.; Patrick J. McCormick, M.D., M.Eng.; Simon Tom, M.D.; Michael F. Aziz, M.D.; Traci Coffman, M.D.; Terri A. Ellis, II, M.D.; Susan Molina, M.D.; William Peterson, M.D.; Sean C. Mackey, M.D., Ph.D.; Wilton A. van Klei, M.D., Ph.D.; Adit A. Ginde, M.D., M.P.H.; Daniel A. Biggs, M.D., M.Sc.; Mark D. Neuman, M.D., M.Sc.; Robert M. Craft, M.D.; Nathan L. Pace, M.D., M.Stat.; William C. Paganelli, M.D., Ph.D.; Marcel E. Durieux, M.D., Ph.D.; Bala J. Nair, Ph.D.; Jonathan P. Wanderer, M.D.; Scott A. Miller, M.D.; Daniel L. Helsten, M.D.; Zachary A. Turnbull, M.D.; Robert B. Schonberger, M.D., M.H.S.
TOPICS: dantrolene, malignant hyperthermia due to anesthesia, succinylcholine, morbidity, mortality, volatile anesthetics
Anesthesiology. 2019; 130(1):41-54. doi: https://doi.org/10.1097/ALN.0000000000002490

Perioperative Medicine February 2015

Factors Associated with Improved Survival after Resection of Pancreatic Adenocarcinoma: A Multivariable Model

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Tyler R. Call, M.D.; Nathan L. Pace, M.D.; Datus B. Thorup, B.S.; Derric Maxfield, M.D.; Ben Chortkoff, M.D.; Joslin Christensen, B.S.; Sean J. Mulvihill, M.D.
TOPICS: cancer survivorship, dexamethasone, pancreatic adenocarcinoma, pancreatic resection, cancer, analgesia, epidural
Anesthesiology. 2015; 122(2):317-324. doi: https://doi.org/10.1097/ALN.0000000000000489

Correspondence December 2014

Questioning a Relationship between Nitrous Oxide Duration of Exposure and Postoperative Nausea and Vomiting

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Nathan L. Pace, M.D., M.Stat.

Anesthesiology. 2014; 121(6):1356-1358. doi: https://doi.org/10.1097/ALN.0000000000000460

Perioperative Medicine August 2012

High Intraoperative Inspired Oxygen Does Not Increase Postoperative Supplemental Oxygen Requirements

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Natalie Mackintosh, M.D.; Matthew C. Gertsch, B.S.; Harriet W. Hopf, M.D.; Nathan L. Pace, M.D., M.Stat.; Julia White, B.S., R.N., C.C.R.C.; Rebecca Morris, B.S.; Candice Morrissey, M.D.; Victoria Wilding, M.D.; Seth Herway, M.D.
TOPICS: intraoperative care, oxygen
Anesthesiology. 2012; 117(2):271-279. doi: https://doi.org/10.1097/ALN.0b013e318259a7e8

Correspondence October 2011

Intrathecal Dosing for Cesarean Delivery in Obese and Nonobese Patients

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Nathan L. Pace, M.D., M.Stat.

Anesthesiology. 2011; 115(4):899-900. doi: https://doi.org/10.1097/ALN.0b013e31822c5f05

Correspondence July 2011

Incomplete Validation of Risk Stratification Indices

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Nathan L. Pace, M.D., M.Stat.

Anesthesiology. 2011; 115(1):214-215. doi: https://doi.org/10.1097/ALN.0b013e31821f6585

Clinical Science May 2008

Part Task and Variable Priority Training in First-year Anesthesia Resident Education: A Combined Didactic and Simulation-based Approach to Improve Management of Adverse Airway and Respiratory Events

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Ken B. Johnson, M.D.; Noah D. Syroid, M.S.; Frank A. Drews, Ph.D.; L Lazarre Ogden, M.D.; David L. Strayer, Ph.D.; Nathan L. Pace, M.D., M.Stat.; Diane L. Tyler, M.S.; Julia L. White, R.N.; Dwayne R. Westenskow, Ph.D.
TOPICS: adult, adverse event, airway device, airway structure, bronchial spasm, internship and residency, medical residencies, pediatrics, intubation, inspiration
Anesthesiology. 2008; 108(5):831-840. doi: https://doi.org/10.1097/ALN.0b013e31816bbd54

Review Article July 2007

Advances in and Limitations of Up-and-down Methodology: A Précis of Clinical Use, Study Design, and Dose Estimation in Anesthesia Research

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Nathan L. Pace, M.D., M.Stat.; Mario P. Stylianou, Ph.D.; David C. Warltier, M.D., Ph.D., Editor
TOPICS: levobupivacaine, mood, probit trial, software, ropivacaine, inference, graphical displays, precision
Anesthesiology. 2007; 107(1):144-152. doi: https://doi.org/10.1097/01.anes.0000267514.42592.2a

Clinical Science March 2007

When Is a Bispectral Index of 60 Too Low?: Rational Processed Electroencephalographic Targets Are Dependent on the Sedative–Opioid Ratio

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Sandeep C. Manyam, Ph.D.; Dhanesh K. Gupta, M.D.; Ken B. Johnson, M.D.; Julia L. White, R.N., B.S., C.C.R.C.; Nathan L. Pace, M.D., M.Stat.; Dwayne R. Westenskow, Ph.D.; Talmage D. Egan, M.D.
TOPICS: bispectral index, electroencephalography, opioid analgesics, opioids, remifentanil, sedation procedure, sevoflurane, sedatives
Anesthesiology. 2007; 106(3):472-483. doi:

Clinical Science August 2006

Opioid–Volatile Anesthetic Synergy: A Response Surface Model with Remifentanil and Sevoflurane as Prototypes

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Sandeep C. Manyam, B.S.; Dhanesh K. Gupta, M.D.; Ken B. Johnson, M.D.; Julia L. White, R.N., B.S., C.C.R.C.; Nathan L. Pace, M.D., M.Stat.; Dwayne R. Westenskow, Ph.D.; Talmage D. Egan, M.D.
TOPICS: opioids, pharmacodynamics, remifentanil, sevoflurane, volatile anesthetics, sedation procedure
Anesthesiology. 2006; 105(2):267-278. doi:

Correspondence June 2006

Better Methods for Meta-analysis Available

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Nathan L. Pace, M.D., M.Stat.

Anesthesiology. 2006; 104(6):1350. doi:

Correspondence February 2005

Improved Statistical Methods for Quantal Assay

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Nathan L. Pace, M.D., M.Stat.

Anesthesiology. 2005; 102(2):476-477. doi:

Meeting Abstracts September 2004

Influence of Hemorrhagic Shock Followed by Crystalloid Resuscitation on Propofol: A Pharmacokinetic and Pharmacodynamic Analysis

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Ken B. Johnson, M.D.; Talmage D. Egan, M.D.; Steven E. Kern, Ph.D.; Scott W. McJames, M.S.; Mark L. Cluff, B.S.; Nathan L. Pace, M.D.

Anesthesiology. 2004; 101(3):647-659. doi:

Clinical Science March 2000

Multiple Dose Pharmacokinetics of Oral Transmucosal Fentanyl Citrate in Healthy Volunteers

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Talmage D. Egan, M.D.; Amarnath Sharma, Ph.D.; Michael A. Ashburn, M.D., M.P.H.; Jur Kievit, M.D.; Nathan L. Pace, M.D., M. Stat.; James B. Streisand, M.D.

Anesthesiology. 2000; 92(3):665-673. doi:

Clinical Science February 1998

Dose Proportionality and Pharmacokinetics of Oral Transmucosal Fentanyl Citrate

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James B. Streisand, MD; Michael A. Busch, PhD; Talmage D. Egan, MD; Barbara Gaylord Smith, RN; Mason Gay, BS; Nathan L. Pace, MD

Anesthesiology. 1998; 88(2):305-309. doi:

Meeting Abstracts March 1995

Buccal Absorption of Fentanyl Is pH-Dependent in Dogs

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James B Streisand, MD; Jie Zhang, PhD; Suyi Niu, MD; Scott McJames, BS; Remco Natte, MD; Nathan L. Pace, MD

Anesthesiology. 1995; 82(3):759-764. doi:

Correspondence August 1993

Pitfalls in Performing Meta-analysis: II Reply

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Nathan L. Pace, M.D.

Anesthesiology. 1993; 79(2):406-408. doi:

Education July 1993

Dose-Response Pharmacology of Intrathecal Morphine in Human Volunteers

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Peter L. Bailey, M.D.; Steven Rhondeau, M.D.; Patrick G. Schafer, M.D.; Jeffrey K. Lu, M.D.; Bryan S. Timmins, M.D.; William Foster, M.D.; Nathan L. Pace, M.D.; Ted H. Stanley, M.D.

Anesthesiology. 1993; 79(1):49-59. doi:

Clinical Science December 1992

Anesthetic Techniques during Surgical Repair of Femoral Neck Fractures: A Meta-analysis

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Robert M. Sorenson, M.D.; Nathan L. Pace, M.D.

Anesthesiology. 1992; 77(6):1095-1104. doi:

Education September 1992

Fentanyl and Sufentanil Increase Intracranial Pressure in Head Trauma Patients

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Richard J. Sperry, M.D.; Peter L. Bailey, M.D.; Mark V. Reichman, M.D.; John C. Peterson, M.D.; Peggy B. Petersen, M.D.; Nathan L. Pace, M.D.

Anesthesiology. 1992; 77(3):416-420. doi:

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Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review

Factors Associated with Improved Survival after Resection of Pancreatic Adenocarcinoma: A Multivariable Model

Questioning a Relationship between Nitrous Oxide Duration of Exposure and Postoperative Nausea and Vomiting

High Intraoperative Inspired Oxygen Does Not Increase Postoperative Supplemental Oxygen Requirements

Intrathecal Dosing for Cesarean Delivery in Obese and Nonobese Patients

Incomplete Validation of Risk Stratification Indices

Part Task and Variable Priority Training in First-year Anesthesia Resident Education: A Combined Didactic and Simulation-based Approach to Improve Management of Adverse Airway and Respiratory Events

Advances in and Limitations of Up-and-down Methodology: A Précis of Clinical Use, Study Design, and Dose Estimation in Anesthesia Research

When Is a Bispectral Index of 60 Too Low?: Rational Processed Electroencephalographic Targets Are Dependent on the Sedative–Opioid Ratio

Opioid–Volatile Anesthetic Synergy: A Response Surface Model with Remifentanil and Sevoflurane as Prototypes

Better Methods for Meta-analysis Available

Improved Statistical Methods for Quantal Assay

Influence of Hemorrhagic Shock Followed by Crystalloid Resuscitation on Propofol: A Pharmacokinetic and Pharmacodynamic Analysis

Multiple Dose Pharmacokinetics of Oral Transmucosal Fentanyl Citrate in Healthy Volunteers

Dose Proportionality and Pharmacokinetics of Oral Transmucosal Fentanyl Citrate

Buccal Absorption of Fentanyl Is pH-Dependent in Dogs

Pitfalls in Performing Meta-analysis: II Reply

Dose-Response Pharmacology of Intrathecal Morphine in Human Volunteers

Anesthetic Techniques during Surgical Repair of Femoral Neck Fractures: A Meta-analysis

Fentanyl and Sufentanil Increase Intracranial Pressure in Head Trauma Patients

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