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Perioperative Medicine May 2019

Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial

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Fleur S. Meijer, M.D.; Chris H. Martini, M.D., Ph.D.; Suzanne Broens, M.D.; Martijn Boon, M.D.; Marieke Niesters, M.D., Ph.D.; Leon Aarts, M.D., Ph.D.; Erik Olofsen, Ph.D.; Monique van Velzen, Ph.D.; Albert Dahan, M.D., Ph.D.
TOPICS: propofol, pain perception, remifentanil, standard of care
Anesthesiology. 2019; 130(5):745-755. doi: 10.1097/ALN.0000000000002634

Perioperative Medicine April 2019

Influence of Reversal of a Partial Neuromuscular Block on the Ventilatory Response to Hypoxia: A Randomized Controlled Trial in Healthy Volunteers

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Suzanne J. L. Broens, M.D.; Martijn Boon, M.D.; Chris H. Martini, M.D., Ph.D.; Marieke Niesters, M.D., Ph.D.; Monique van Velzen, Ph.D.; Leon P. H. J. Aarts, M.D., Ph.D.; Albert Dahan, M.D., Ph.D.
TOPICS: hypoxia, end tidal carbon dioxide concentration, neostigmine, carotid body, neuromuscular blockade monitoring, induction of neuromuscular blockade, rocuronium, sugammadex, train-of-four monitoring
Anesthesiology. 2019; doi: 10.1097/ALN.0000000000002711

Perioperative Medicine August 2018

Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(–) Ketamine Concentrations

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Thomas K. Henthorn, M.D.; Michael J. Avram, Ph.D.; Albert Dahan, M.D., Ph.D.; Lars L. Gustafsson, M.D., Ph.D.; Jan Persson, M.D., Ph.D.; Tom C. Krejcie, M.D.; Erik Olofsen, Ph.D.
TOPICS: ketamine, plasma, arm, drug concentration, infusion procedures
Anesthesiology. 2018; 129(2):260-270. doi: 10.1097/ALN.0000000000002265

Pain Medicine May 2018

Benefit versus Severe Side Effects of Opioid Analgesia: Novel Utility Functions of Probability of Analgesia and Respiratory Depression

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Margot Roozekrans, M.D.; Rutger van der Schrier, M.D.; Leon Aarts, M.D., Ph.D.; Elise Sarton, M.D., Ph.D.; Monique van Velzen, Ph.D.; Marieke Niesters, M.D., Ph.D.; Albert Dahan, M.D., Ph.D.; Erik Olofsen, Ph.D.
TOPICS: alfentanil, opioid analgesics, pain management, analgesia (pain absence), pharmacodynamics, opioids, respiratory depression
Anesthesiology. 2018; 128(5):932-942. doi: 10.1097/ALN.0000000000002138

Pain Medicine May 2018

Pharmacokinetic Properties of a Sufentanil Sublingual Tablet Intended to Treat Acute Pain

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Dennis M. Fisher, M.D.; Peter Chang, Ph.D.; D. Russell Wada, Ph.D.; Albert Dahan, M.D., Ph.D.; Pamela P. Palmer, M.D., Ph.D.
TOPICS: plasma drug concentration, sublingual drug administration, sufentanil, tablet dosage form, therapeutics, pharmacokinetics, acute pain, sublingual tablet
Anesthesiology. 2018; 128(5):943-952. doi: 10.1097/ALN.0000000000002145

Education May 2018

Averting Opioid-induced Respiratory Depression without Affecting Analgesia

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Albert Dahan, M.D., Ph.D.; Rutger van der Schrier, M.D.; Terry Smith, Ph.D.; Leon Aarts, M.D.; Monique van Velzen, Ph.D.; Marieke Niesters, M.D., Ph.D.
TOPICS: opioid analgesics, pain management, analgesia (pain absence), carotid body, agonists, opioids, respiratory depression, respiratory stimulants
Anesthesiology. 2018; 128(5):1027-1037. doi: 10.1097/ALN.0000000000002184

Pain Medicine October 2017

Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers

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Kelly Jonkman, M.D.; Andreas Duma, M.D.; Erik Olofsen, M.Sc.; Thomas Henthorn, M.D.; Monique van Velzen, Ph.D.; René Mooren, B.Sc.; Liesbeth Siebers, B.Sc.; Jojanneke van den Beukel, B.Sc.; Leon Aarts, M.D., Ph.D.; Marieke Niesters, M.D., Ph.D.; Albert Dahan, M.D., Ph.D.
TOPICS: process of absorption, biological availability, lung, inspiration, ketamine, pharmacokinetics
Anesthesiology. 2017; 127(4):675-683. doi: 10.1097/ALN.0000000000001798

Pain Medicine April 2017

Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers

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Albert Dahan, M.D., Ph.D.; Merel Boom, M.D., Ph.D.; Elise Sarton, M.D., Ph.D.; Justin Hay, Ph.D.; Geert Jan Groeneveld, M.D., Ph.D.; Meike Neukirchen, Ph.D.; John Bothmer, Ph.D.; Leon Aarts, M.D., Ph.D.; Erik Olofsen, M.Sc.
TOPICS: plasma drug concentration, respiration, opioid analgesics, pain, pain threshold, peptides, opioid receptor, pain management, analgesia (pain absence), carbon dioxide, environmental air flow, pharmacodynamics, agonists, nociceptin, opioids, respiratory depression
Anesthesiology. 2017; 126(4):697-707. doi: 10.1097/ALN.0000000000001529

Pain Medicine March 2017

Influence of Ethanol on Oxycodone-induced Respiratory Depression: A Dose-escalating Study in Young and Elderly Individuals

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Rutger van der Schrier, M.D.; Margot Roozekrans, M.D.; Erik Olofsen, M.Sc.; Leon Aarts, M.D., Ph.D.; Monique van Velzen, Ph.D.; Merijn de Jong, B.Sc.; Albert Dahan, M.D., Ph.D.; Marieke Niesters, M.D., Ph.D.
TOPICS: ethanol, respiration, apnea, oxycodone, elderly, respiratory depression
Anesthesiology. 2017; 126(3):534-542. doi: 10.1097/ALN.0000000000001505

Editorial Views November 2016

Potent Opioid Analgesia without Respiratory Depression: Could It Be Possible?

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Albert Dahan, M.D., Ph.D.
TOPICS: opioid analgesics, pain management, analgesia (pain absence), opioids, respiratory depression
Anesthesiology. 2016; 125(5):841-843. doi: 10.1097/ALN.0000000000001321

Editorial Views March 2016

Arterial Line Placement: Safety First

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Albert Dahan, M.D., Ph.D.; Dirk P. Engberts, M.A., L.L.M., Ph.D.; Marieke Niesters, M.D., Ph.D.
TOPICS: safety, arterial catheterization
Anesthesiology. 2016; 124(3):528-529. doi: 10.1097/ALN.0000000000000968

Perioperative Medicine September 2015

Ability of the Nociception Level, a Multiparameter Composite of Autonomic Signals, to Detect Noxious Stimuli during Propofol–Remifentanil Anesthesia

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Chris H. Martini, M.D.; Martijn Boon, M.D.; Suzanne J. L. Broens, M.D.; Evelien F. Hekkelman, M.D.; Lisanne A. Oudhoff, M.D.; Anna Willemijn Buddeke, M.D.; Albert Dahan, M.D., Ph.D.

Anesthesiology. 2015; 123(3):524-534. doi: 10.1097/ALN.0000000000000757

Editorial Views April 2015

Endogenous Pain Modulation: From Humans to Animals and Back

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David Yarnitsky, M.D.; Albert Dahan, M.D., Ph.D.
TOPICS: pain, pain management, endogenous factors
Anesthesiology. 2015; 122(4):734-735. doi: 10.1097/ALN.0000000000000594

Editorial Views January 2015

Big Brain, Small World?

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Erik Olofsen, M.Sc.; Albert Dahan, M.D., Ph.D.
TOPICS: brain, graphical displays
Anesthesiology. 2015; 122(1):8-11. doi: 10.1097/ALN.0000000000000517

Editorial Views October 2014

Comorbidities and the Complexities of Chronic Pain

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Albert Dahan, M.D., Ph.D.; Monique van Velzen, Ph.D.; Marieke Niesters, M.D., M.Sc.
TOPICS: comorbidity, chronic pain
Anesthesiology. 2014; 121(4):675-677. doi: 10.1097/ALN.0000000000000402

Perioperative Medicine September 2014

Two Studies on Reversal of Opioid-induced Respiratory Depression by BK-channel Blocker GAL021 in Human Volunteers

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Margot Roozekrans, M.D.; Rutger van der Schrier, M.D.; Pieter Okkerse, M.D.; Justin Hay, Ph.D.; James F. McLeod, M.D.; Albert Dahan, M.D., Ph.D.
TOPICS: hemodynamics, respiration, alfentanil, safety, pain management, environmental air flow, sedation procedure, opioids, respiratory depression, infusion procedures
Anesthesiology. 2014; 121(3):459-468. doi: 10.1097/ALN.0000000000000367

Editorial Views July 2014

Ketamine Metabolomics in the Treatment of Major Depression

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Monique van Velzen, Ph.D.; Albert Dahan, M.D., Ph.D.
TOPICS: ketamine, major depressive disorder, metabolomics
Anesthesiology. 2014; 121(1):4-5. doi: 10.1097/ALN.0000000000000286

Pain Medicine September 2013

Fentanyl Utility Function: A Risk–Benefit Composite of Pain Relief and Breathing Responses

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Merel Boom, M.D.; Erik Olofsen, M.Sc.; Meike Neukirchen, Ph.D.; René Fussen, Dr. Med., M.D.; Justin Hay, Ph.D.; Geert Jan Groeneveld, M.D., Ph.D.; Leon Aarts, M.D., Ph.D.; Elise Sarton, M.D., Ph.D.; Albert Dahan, M.D., Ph.D.
TOPICS: fentanyl, respiration, inspiration, pain, pain management, analgesia (pain absence), pharmacodynamics, respiratory depression
Anesthesiology. 2013; 119(3):663-674. doi: 10.1097/ALN.0b013e31829ce4cb

Editorial Views June 2013

Primum Non Nocere or How to Resolve Drug-induced Respiratory Depression

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Albert Dahan, M.D., Ph.D.; Margot Roozekrans, M.D.; Rutger van der Schrier, M.D.; Terry Smith, Ph.D.; Leon Aarts, M.D., Ph.D.
TOPICS: respiratory depression, respiratory stimulants
Anesthesiology. 2013; 118(6):1261-1263. doi: 10.1097/ALN.0b013e31829107d5

Pain Medicine October 2012

Effect of Subanesthetic Ketamine on Intrinsic Functional Brain Connectivity: A Placebo-controlled Functional Magnetic Resonance Imaging Study in Healthy Male Volunteers

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Marieke Niesters, M.D., M.Sc.; Najmeh Khalili-Mahani, Ph.D.; Christian Martini, M.D.; Leon Aarts, M.D., Ph.D.; Joop van Gerven, M.D., Ph.D.; Mark A. van Buchem, M.D., Ph.D.; Albert Dahan, M.D., Ph.D.; Serge Rombouts, Ph.D.
TOPICS: ketamine, pain, brain, functional magnetic resonance imaging
Anesthesiology. 2012; 117(4):868-877. doi: 10.1097/ALN.0b013e31826a0db3

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Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial

Influence of Reversal of a Partial Neuromuscular Block on the Ventilatory Response to Hypoxia: A Randomized Controlled Trial in Healthy Volunteers

Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(–) Ketamine Concentrations

Benefit versus Severe Side Effects of Opioid Analgesia: Novel Utility Functions of Probability of Analgesia and Respiratory Depression

Pharmacokinetic Properties of a Sufentanil Sublingual Tablet Intended to Treat Acute Pain

Averting Opioid-induced Respiratory Depression without Affecting Analgesia

Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers

Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers

Influence of Ethanol on Oxycodone-induced Respiratory Depression: A Dose-escalating Study in Young and Elderly Individuals

Potent Opioid Analgesia without Respiratory Depression: Could It Be Possible?

Arterial Line Placement: Safety First

Ability of the Nociception Level, a Multiparameter Composite of Autonomic Signals, to Detect Noxious Stimuli during Propofol–Remifentanil Anesthesia

Endogenous Pain Modulation: From Humans to Animals and Back

Big Brain, Small World?

Comorbidities and the Complexities of Chronic Pain

Two Studies on Reversal of Opioid-induced Respiratory Depression by BK-channel Blocker GAL021 in Human Volunteers

Ketamine Metabolomics in the Treatment of Major Depression

Fentanyl Utility Function: A Risk–Benefit Composite of Pain Relief and Breathing Responses

Primum Non Nocere or How to Resolve Drug-induced Respiratory Depression

Effect of Subanesthetic Ketamine on Intrinsic Functional Brain Connectivity: A Placebo-controlled Functional Magnetic Resonance Imaging Study in Healthy Male Volunteers

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