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Table of Contents

Anesthesiology Free
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Anesthesiology May 2018, Vol.128, A1-A6. doi:https://doi.org/10.1097/ALN.0000000000002241

Editorial Board

Anesthesiology Free
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Anesthesiology May 2018, Vol.128, A11-A12. doi:https://doi.org/10.1097/ALN.0000000000002221

This Month in Anesthesiology

This Month in Anesthesiology Free
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Anesthesiology May 2018, Vol.128, A1-A2. doi:https://doi.org/10.1097/ALN.0000000000002220

Science, Medicine, and the Anesthesiologist

Science, Medicine, and the Anesthesiologist Free
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Anesthesiology May 2018, Vol.128, A15-A18. doi:https://doi.org/10.1097/ALN.0000000000002223

Infographics in Anesthesiology

Reducing Harm from Opioids: New Approaches for a Pressing Problem Free
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Jonathan P. Wanderer; James P. Rathmell
Tags: opioids
Anesthesiology May 2018, Vol.128, A19. doi:https://doi.org/10.1097/ALN.0000000000002224

Anesthesiology CME Program

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit Free
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Anesthesiology May 2018, Vol.128, A13. doi:https://doi.org/10.1097/ALN.0000000000002222

Editorial

Frontiers in Opioid Pharmacology Free
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James P. Rathmell, M.D.; Evan D. Kharasch, M.D., Ph.D.
Tags: opioid analgesics, opioids, pharmacology
Anesthesiology May 2018, Vol.128, 865-866. doi:https://doi.org/10.1097/ALN.0000000000002193
μ-Opioid Receptor Agonists: Do They Have Utility in the Treatment of Acute Pain? Free
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Thomas K. Henthorn, M.D.; Susan K. Mikulich-Gilbertson, Ph.D.
Tags: acute pain, agonists, opioids, respiratory depression, pain management
Anesthesiology May 2018, Vol.128, 867-870. doi:https://doi.org/10.1097/ALN.0000000000002177
The Heat Is On: Clinical Implications of Intraoperative Thermoregulation Research Free
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David A. Story, M.D., F.A.N.Z.C.A.
Tags: body temperature regulation, heat (physical force), intraoperative care
Anesthesiology May 2018, Vol.128, 871-872. doi:https://doi.org/10.1097/ALN.0000000000002154

Special Articles

Does Aerobic Respiration Produce Carbon Dioxide or Hydrogen Ion and Bicarbonate? Free
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Erik R. Swenson, M.D.
Tags: bicarbonates, carbon dioxide, cell respiration, protons, citric acid cycle
Anesthesiology May 2018, Vol.128, 873-879. doi:https://doi.org/10.1097/ALN.0000000000002125

Anesthesiology Reflections from the Wood Library-Museum

Charles Halpine or How Chloroform Killed Simultaneously a General and a Private Free
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Anesthesiology May 2018, Vol.128, 879. doi:https://doi.org/10.1097/ALN.0000000000002215

Perioperative Medicine Clinical Science

Opioid Abuse or Dependence Increases 30-day Readmission Rates after Major Operating Room Procedures: A National Readmissions Database Study Free
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Atul Gupta, M.D.; Junaid Nizamuddin, M.D.; Dalia Elmofty, M.D.; Sarah L. Nizamuddin, M.D.; Avery Tung, M.D.; Mohammed Minhaj, M.D., M.B.A.; Ariel Mueller, M.A.; Jeffrey Apfelbaum, M.D.; Sajid Shahul, M.D., M.P.H.
Tags: operating room, opioid abuse, patient readmission
Anesthesiology May 2018, Vol.128, 880-890. doi:https://doi.org/10.1097/ALN.0000000000002136

Anesthesiology Reflections from the Wood Library-Museum

Yellow Journalism Highlights Postanesthetic Complications: Pulitzer versus Hearst Free
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Anesthesiology May 2018, Vol.128, 890. doi:https://doi.org/10.1097/ALN.0000000000002216

Perioperative Medicine Clinical Science

Association of Multimodal Pain Management Strategies with Perioperative Outcomes and Resource Utilization: A Population-based Study Free
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Stavros G. Memtsoudis, M.D., Ph.D., F.C.C.P.; Jashvant Poeran, M.D., Ph.D.; Nicole Zubizarreta, M.P.H.; Crispiana Cozowicz, M.D.; Eva E. Mörwald, M.D.; Edward R. Mariano, M.D., M.A.S.; Madhu Mazumdar, Ph.D.
Tags: opioids, pain management, hip region, knee replacement arthroplasty, analgesics
Anesthesiology May 2018, Vol.128, 891-902. doi:https://doi.org/10.1097/ALN.0000000000002132
Effects of Ambient Temperature and Forced-air Warming on Intraoperative Core Temperature: A Factorial Randomized Trial Free
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Lijian Pei, M.D.; Yuguang Huang, M.D.; Yiyao Xu, M.D.; Yongchang Zheng, M.D.; Xinting Sang, M.D.; Xiaoyun Zhou, M.D.; Shanqing Li, M.D.; Guangmei Mao, Ph.D.; Edward J. Mascha, Ph.D.; Daniel I. Sessler, M.D.
Tags: ambient temperature, core body temperature, intraoperative care, temperature, surgical procedures, operative
Anesthesiology May 2018, Vol.128, 903-911. doi:https://doi.org/10.1097/ALN.0000000000002099

Perioperative Medicine Basic Science

Influence of Cardiac Output on the Pharmacokinetics of Sufentanil in Anesthetized Pigs Free
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Torsten Birkholz, M.D.; Christian Leuthold, M.D.; Joachim Schmidt, M.D.; Harald Ihmsen, Ph.D.; Jürgen Schüttler, M.D.; Christian Jeleazcov, M.D., M.Sc.
Tags: cardiac output, pharmacokinetics, sufentanil, suidae, plasma drug concentration
Anesthesiology May 2018, Vol.128, 912-920. doi:https://doi.org/10.1097/ALN.0000000000002160
Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein–induced Inflammation through a Vagomimetic Action in Mice Free
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Jun Hu, M.D.; Susana Vacas, M.D., Ph.D.; Xiaomei Feng, M.D., Ph.D.; David Lutrin, M.D.; Yosuke Uchida, M.D., Ph.D.; Ieng Kit Lai, B.S.; Mervyn Maze, M.B.Ch.B.
Tags: cognitive impairment, dexmedetomidine, hmgb1 protein, inflammation, mice
Anesthesiology May 2018, Vol.128, 921-931. doi:https://doi.org/10.1097/ALN.0000000000002038

Pain Medicine Clinical Science

Benefit versus Severe Side Effects of Opioid Analgesia: Novel Utility Functions of Probability of Analgesia and Respiratory Depression Free
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Margot Roozekrans, M.D.; Rutger van der Schrier, M.D.; Leon Aarts, M.D., Ph.D.; Elise Sarton, M.D., Ph.D.; Monique van Velzen, Ph.D.; Marieke Niesters, M.D., Ph.D.; Albert Dahan, M.D., Ph.D.; Erik Olofsen, Ph.D.
Tags: alfentanil, analgesia (pain absence), opioid analgesics, opioids, pain management
Anesthesiology May 2018, Vol.128, 932-942. doi:https://doi.org/10.1097/ALN.0000000000002138
Pharmacokinetic Properties of a Sufentanil Sublingual Tablet Intended to Treat Acute Pain Free
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Dennis M. Fisher, M.D.; Peter Chang, Ph.D.; D. Russell Wada, Ph.D.; Albert Dahan, M.D., Ph.D.; Pamela P. Palmer, M.D., Ph.D.
Tags: acute pain, plasma drug concentration, sublingual drug administration, sublingual tablet, sufentanil
Anesthesiology May 2018, Vol.128, 943-952. doi:https://doi.org/10.1097/ALN.0000000000002145
New Opioid Analgesic Approvals and Outpatient Utilization of Opioid Analgesics in the United States, 1997 through 2015 Free
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Grace Chai, Pharm.D.; Jing Xu, Ph.D., M.A.; James Osterhout, Ph.D.; Mark A. Liberatore, Pharm.D., R.A.C.; Kathleen L. Miller, Ph.D.; Carolyn Wolff, Ph.D.; Marisa Cruz, M.D.; Peter Lurie, M.D., M.P.H.; Gerald Dal Pan, M.D., M.H.S.
Tags: opioid analgesics, outpatients
Anesthesiology May 2018, Vol.128, 953-966. doi:https://doi.org/10.1097/ALN.0000000000002187

Pain Medicine Basic Science

Overexpression of µ-Opioid Receptors in Peripheral Afferents, but Not in Combination with Enkephalin, Decreases Neuropathic Pain Behavior and Enhances Opioid Analgesia in Mouse Free
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Amanda H. Klein, Ph.D., M.S.; Husam K. Mohammad, Ph.D., R.Ph.; Rabiah Ali, M.D.; Brad Peper, D.M.D.; Steven P. Wilson, Ph.D.; Srinivasa N. Raja, M.D.; Matthias Ringkamp, M.D., Ph.D.; Sarah Sweitzer, Ph.D.
Tags: capsaicin, enkephalins, hyperalgesia, mice, morphine
Anesthesiology May 2018, Vol.128, 967-983. doi:https://doi.org/10.1097/ALN.0000000000002063
Buprenorphine Depresses Respiratory Variability in Obese Mice with Altered Leptin Signaling Free
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Chelsea Angel, B.A.; Zachary T. Glovak, B.A.; Wateen Alami, B.A.; Sara Mihalko, B.A.; Josh Price, M.S.; Yandong Jiang, M.D., Ph.D.; Helen A. Baghdoyan, Ph.D.; Ralph Lydic, Ph.D.
Tags: buprenorphine, leptin, mice, mice, obese, signal transduction
Anesthesiology May 2018, Vol.128, 984-991. doi:https://doi.org/10.1097/ALN.0000000000002073

Anesthesiology Reflections from the Wood Library-Museum

Streams of Unconsciousness II: Hypnosis Reflected in the Styx Free
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Anesthesiology May 2018, Vol.128, 991. doi:https://doi.org/10.1097/ALN.0000000000002217

Pain Medicine Basic Science

Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats Free
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Satoshi Toyama, M.D., Ph.D.; Naohito Shimoyama, M.D., Ph.D.; Yugo Tagaito, M.D., Ph.D.; Hiroshi Nagase, Ph.D.; Tsuyoshi Saitoh, Ph.D.; Masashi Yanagisawa, M.D., Ph.D.; Megumi Shimoyama, M.D., Ph.D.
Tags: electroencephalography, morphine, orexins, rats
Anesthesiology May 2018, Vol.128, 992-1003. doi:https://doi.org/10.1097/ALN.0000000000002161

Education Images in Anesthesiology

Images in Anesthesiology: Spinal Subdural Hematoma after Spinal Drain for Endovascular Thoracic Aortic Aneurysm Repair Free
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Hamdy Awad, M.D.; Tsung-Pai J. Huang, M.S.; Esmerina Tili, Ph.D.; Eric Bourekas, M.D.
Tags: hematoma, subdural, thoracic aortic aneurysm repair
Anesthesiology May 2018, Vol.128, 1004. doi:https://doi.org/10.1097/ALN.0000000000001995
Takayasu Arteritis and Complete Aortic Arch Branch Vessel Occlusions Free
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Shane M. Gillespie, D.O.; Stephen M. Broski, M.D.; David W. Barbara, M.D.
Tags: aortic arch, takayasu's arteritis
Anesthesiology May 2018, Vol.128, 1005. doi:https://doi.org/10.1097/ALN.0000000000001996
Hemopericardium and Acute Cardiac Tamponade Free
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Sandeep Khanna, M.D.; Kamal Maheshwari, M.D., M.P.H.
Tags: cardiac tamponade
Anesthesiology May 2018, Vol.128, 1006. doi:https://doi.org/10.1097/ALN.0000000000001999
Cervical Deformity and Potential Difficult Airway Management in Klippel–Feil Syndrome Free
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Mamta Chura, M.B.B.S.; Nadine Odo, B.A., E.L.S.; Edward Foley, M.D.; Vaibhav Bora, M.B.B.S.
Tags: intubation, difficult, klippel-feil syndrome
Anesthesiology May 2018, Vol.128, 1007. doi:https://doi.org/10.1097/ALN.0000000000002015

Education Clinical Focus Review

Neurologic Considerations and Complications Related to Liver Transplantation Free
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Sathish S. Kumar, M.B.B.S.; George A. Mashour, M.D., Ph.D.; Paul Picton, M.D.
Tags: liver transplantation, neurologic complications, hepatic encephalopathy
Anesthesiology May 2018, Vol.128, 1008-1014. doi:https://doi.org/10.1097/ALN.0000000000002148

Education Review Article

Abuse-deterrent Opioid Formulations Free
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Ronald S. Litman, D.O.; Olivia H. Pagán; Theodore J. Cicero, Ph.D.
Tags: abuse-deterrent opioids, nose, opioids, oxycodone, united states food and drug administration
Anesthesiology May 2018, Vol.128, 1015-1026. doi:https://doi.org/10.1097/ALN.0000000000002031
Averting Opioid-induced Respiratory Depression without Affecting Analgesia Free
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Albert Dahan, M.D., Ph.D.; Rutger van der Schrier, M.D.; Terry Smith, Ph.D.; Leon Aarts, M.D.; Monique van Velzen, Ph.D.; Marieke Niesters, M.D., Ph.D.
Tags: analgesia (pain absence), opioid analgesics, opioids, pain management, respiratory depression
Anesthesiology May 2018, Vol.128, 1027-1037. doi:https://doi.org/10.1097/ALN.0000000000002184

Education Mind to Mind

Your Anesthesiologist Self Free
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Audrey Shafer
Tags: elation, elbow region, eyelid, fingers, food
Anesthesiology May 2018, Vol.128, 1038-1039. doi:https://doi.org/10.1097/ALN.0000000000002126
Fear in Perspective Free
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Mary F. Chisholm, M.D.
Tags: fear
Anesthesiology May 2018, Vol.128, 1040-1042. doi:https://doi.org/10.1097/ALN.0000000000002088

Correspondence

Challenge of the Mini-fluid Challenge: Filling Twice without Creating a Self-fulfilling Prophecy Design Free
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Simon Tilma Vistisen, Ph.D., M.Sc.; Thomas W. L. Scheeren, M.D., Ph.D.
Anesthesiology May 2018, Vol.128, 1043-104