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Table of Contents

Anesthesiology Free
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Anesthesiology March 2014, Vol.120, A4-A9. doi:10.1097/01.anes.0000444097.07081.9d

Editorial Board

Anesthesiology Free
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Anesthesiology March 2014, Vol.120, A10-A11. doi:10.1097/01.anes.0000444096.99456.72

This Month in Anesthesiology

This Month In: Anesthesiology Free
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Anesthesiology March 2014, Vol.120, A1-A2. doi:10.1097/01.anes.0000444094.61338.ca

Science, Medicine, and the Anesthesiologist

Science, Medicine, and the Anesthesiologist: Key Papers from the Most Recent Literature Relevant to Anesthesiologists Free
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Anesthesiology March 2014, Vol.120, A13-A14. doi:10.1097/01.anes.0000444098.84209.85

Infographics in Anesthesiology

Complex Information for Anesthesiologists Presented Quickly and Clearly: Knee and Hip Arthroplasty: Variations in Use of Regional Anesthesia Free
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Tags: anesthesia, conduction, hip replacement arthroplasty, knee joint, knee region
Anesthesiology March 2014, Vol.120, A3. doi:10.1097/01.anes.0000444099.91832.9c

Anesthesiology CME Program

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit Free
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Anesthesiology March 2014, Vol.120, A12. doi:10.1097/01.anes.0000444095.99456.a9

Editorial Views

In the Land of the Blind, the One-eyed Man Is King Free
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Sachin Kheterpal, M.D., M.B.A.
Tags: community, data mining, patient safety, infection, surgical procedures, operative
Anesthesiology March 2014, Vol.120, 523-525. doi:10.1097/ALN.0000000000000123

Anesthesiology Reflections from the Wood Library-Museum

The Bookplate of Paul M. Wood, M.D. Free
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Anesthesiology March 2014, Vol.120, 525. doi:10.1097/01.anes.0000444100.85995.fe

Editorial Views

From Heroism to Safe Design: Leveraging Technology Free
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Peter J. Pronovost, M.D., Ph.D.; George W. Bo-Linn, M.D., M.H.A.; Adam Sapirstein, M.D.
Tags: electronic medical records, engineering, intensive care unit, investments, patient safety
Anesthesiology March 2014, Vol.120, 526-529. doi:10.1097/ALN.0000000000000127
Adductor Canal Block for Total Knee Arthroplasty: The Perfect Recipe or Just One Ingredient? Free
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Edward R. Mariano, M.D., M.A.S. (Clinical Research); Anahi Perlas, M.D., F.R.C.P.C.
Tags: knee replacement arthroplasty
Anesthesiology March 2014, Vol.120, 530-532. doi:10.1097/ALN.0000000000000121
TnT: Blowing the Cover from Perioperative Myocardial Injury Free
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Karsten Bartels, M.D.; Breandan L. Sullivan, M.D.; Holger K. Eltzschig, M.D., Ph.D.
Tags: myocardial injury, troponin t
Anesthesiology March 2014, Vol.120, 533-535. doi:10.1097/ALN.0000000000000112

Anesthesiology Reflections from the Wood Library-Museum

Longnecker’s Trade Card against the “Asphyxie” of “The Old Way” Free
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Anesthesiology March 2014, Vol.120, 535. doi:10.1097/01.anes.0000444101.85995.b7

Editorial Views

Therapeutic Range of Spontaneous Breathing during Mechanical Ventilation Free
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Matthias Eikermann, M.D., Ph.D.; Marcos F. Vidal Melo, M.D., Ph.D.
Tags: inspiration, mechanical ventilation, respiration, therapeutic index
Anesthesiology March 2014, Vol.120, 536-539. doi:10.1097/ALN.0000000000000126

Perioperative Medicine Clinical Science

Adductor Canal Block versus Femoral Nerve Block for Total Knee Arthroplasty: A Prospective, Randomized, Controlled Trial Free
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David H. Kim, M.D.; Yi Lin, M.D., Ph.D.; Enrique A. Goytizolo, M.D.; Richard L. Kahn, M.D.; Daniel B. Maalouf, M.D., M.P.H.; Asha Manohar, M.D.; Minda L. Patt, M.D.; Amanda K. Goon, B.A.; Yuo-yu Lee, M.S.; Yan Ma, Ph.D.; Jacques T. YaDeau, M.D., Ph.D.
Tags: knee replacement arthroplasty, local anesthetic femoral nerve block, opioids, pain score, quadriceps
Anesthesiology March 2014, Vol.120, 540-550. doi:10.1097/ALN.0000000000000119

Anesthesiology Reflections from the Wood Library-Museum

Dr. Paul Wood’s Academy of Anesthesiology “Active Membership” Certificate Free
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Anesthesiology March 2014, Vol.120, 550. doi:10.1097/01.anes.0000444102.93618.2f

Perioperative Medicine Clinical Science

Inpatient Falls after Total Knee Arthroplasty: The Role of Anesthesia Type and Peripheral Nerve Blocks Free
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Stavros G. Memtsoudis, M.D., Ph.D., F.C.C.P.; Thomas Danninger, M.D.; Rehana Rasul, M.P.H., M.A.; Jashvant Poeran, M.D., Ph.D.; Philipp Gerner, B.S.; Ottokar Stundner, M.D.; Edward R. Mariano, M.D., M.A.S.; Madhu Mazumdar, Ph.D., M.A., M.S.
Tags: anesthesia, general, comorbidity, inpatients, knee replacement arthroplasty, neuraxial anesthesia
Anesthesiology March 2014, Vol.120, 551-563. doi:10.1097/ALN.0000000000000120
Myocardial Injury after Noncardiac Surgery: A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes Free
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Tags: diagnosis, ischemia, mortality, myocardial injury, surgery specialty
Anesthesiology March 2014, Vol.120, 564-578. doi:10.1097/ALN.0000000000000113
Etomidate Use and Postoperative Outcomes among Cardiac Surgery Patients Free
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Chad E. Wagner, M.D.; Julian S. Bick, M.D.; Daniel Johnson, Pharm.D.; Rashid Ahmad, M.D.; Xue Han, M.P.H.; Jesse M. Ehrenfeld, M.D.; Jonathan S. Schildcrout, Ph.D.; Mias Pretorius, M.B.Ch.B., M.S.C.I.
Tags: cardiac surgery procedures, etomidate, surgical outcome, mechanical ventilation, hypotension
Anesthesiology March 2014, Vol.120, 579-589. doi:10.1097/ALN.0000000000000087
Comparison of Two Doses of Tranexamic Acid in Adults Undergoing Cardiac Surgery with Cardiopulmonary Bypass Free
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Stéphanie Sigaut, M.D.; Benjamin Tremey, M.D.; Alexandre Ouattara, M.D., Ph.D.; Roland Couturier, M.D.; Christian Taberlet, M.D.; Stanislas Grassin-Delyle, Pharm.D., Ph.D.; Jean-Francois Dreyfus, M.D., Ph.D.; Sylvie Schlumberger, M.D.; Marc Fischler, M.D.
Tags: adult, blood products, cardiac surgery procedures, cardiopulmonary bypass, hemorrhage
Anesthesiology March 2014, Vol.120, 590-600. doi:10.1097/ALN.0b013e3182a443e8
A Pilot Study Evaluating Presurgery Neuroanatomical Biomarkers for Postoperative Cognitive Decline after Total Knee Arthroplasty in Older Adults Free
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Catherine C. Price, Ph.D.; Jared J. Tanner, Ph.D.; Ilona Schmalfuss, M.D.; Cynthia Wilson Garvan, Ph.D.; Peter Gearen, M.D.; David Dickey, Ph.D.; Kenneth Heilman, M.D.; David L. McDonagh, M.D.; David J. Libon, Ph.D.; Christiana Leonard, Ph.D.; Dawn Bowers, Ph.D.; Terri G. Monk, M.D., M.S.
Tags: cognitive impairment, elderly, knee replacement arthroplasty, leukoaraiosis, memory
Anesthesiology March 2014, Vol.120, 601-613. doi:10.1097/ALN.0000000000000080
A Phase I, Dose-escalation Trial Evaluating the Safety and Efficacy of Emulsified Isoflurane in Healthy Human Volunteers Free
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Han Huang, M.D.; Rui Li, M.D.; Jin Liu, M.D.; Wensheng Zhang, M.D.; Tianzhi Liao, B.S.; Xiaoqian Yi, M.S.
Tags: isoflurane, safety
Anesthesiology March 2014, Vol.120, 614-625. doi:10.1097/ALN.0000000000000044

Perioperative Medicine Basic Science

Isoflurane-induced Apoptosis of Neurons and Oligodendrocytes in the Fetal Rhesus Macaque Brain Free
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Catherine E. Creeley, Ph.D.; Krikor T. Dikranian, M.D., Ph.D.; Gregory A. Dissen, Ph.D.; Stephen A. Back, M.D., Ph.D.; John W. Olney, M.D.; Ansgar M. Brambrink, M.D., Ph.D.
Tags: apoptosis, brain, fetus, isoflurane, neurons
Anesthesiology March 2014, Vol.120, 626-638. doi:10.1097/ALN.0000000000000037
Tranexamic Acid Impairs γ-Aminobutyric Acid Receptor Type A–mediated Synaptic Transmission in the Murine Amygdala: A Potential Mechanism for Drug-induced Seizures? Free
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Stephan Kratzer, M.D.; Hedwig Irl, M.S.; Corinna Mattusch, Ph.D.; Martina Bürge, M.D.; Jörg Kurz, M.D.; Eberhard Kochs, M.D.; Matthias Eder, Ph.D.; Gerhard Rammes, Ph.D.; Rainer Haseneder, M.D.
Tags: amygdala, myanmar, seizures, withdrawal, synaptic transmission, tranexamic acid
Anesthesiology March 2014, Vol.120, 639-649. doi:10.1097/ALN.0000000000000103

Critical Care Medicine Clinical Science

Variation of Arterial and Central Venous Catheter Use in United States Intensive Care Units Free
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Hayley B. Gershengorn, M.D.; Allan Garland, M.D., M.A.; Andrew Kramer, Ph.D.; Damon C. Scales, M.D., Ph.D.; Gordon Rubenfeld, M.D., M.Sc.; Hannah Wunsch, M.D., M.Sc.
Tags: catheters, central venous catheters, intensive care unit, abdominal compartment syndrome, acute coronary syndromes
Anesthesiology March 2014, Vol.120, 650-664. doi:10.1097/ALN.0000000000000008

Critical Care Medicine Basic Science

Sedation Using Propofol Induces Similar Diaphragm Dysfunction and Atrophy during Spontaneous Breathing and Mechanical Ventilation in Rats Free
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Christian S. Bruells, M.D.; Karen Maes, Ph.D.; Rolf Rossaint, M.D.; Debby Thomas, M.S.; Nele Cielen, M.S.; Ingmar Bergs, M.D.; Christian Bleilevens, M.S.; Joachim Weis, M.D.; Ghislaine Gayan-Ramirez, Ph.D.
Tags: atrophy, mechanical ventilation, propofol, rats, respiration
Anesthesiology March 2014, Vol.120, 665-672. doi:10.1097/ALN.0000000000000125
Higher Levels of Spontaneous Breathing Induce Lung Recruitment and Reduce Global Stress/Strain in Experimental Lung Injury Free
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Andreas Güldner, M.D.; Anja Braune, M.Sc.; Nadja Carvalho, Ph.D.; Alessandro Beda, Ph.D.; Stefan Zeidler, M.S.; Bärbel Wiedemann, Ph.D.; Gerd Wunderlich, Ph.D.; Michael Andreeff, Ph.D.; Christopher Uhlig, M.D.; Peter M. Spieth, M.D.; Thea Koch, M.D., Ph.D.; Paolo Pelosi, M.D.; Jörg Kotzerke, M.D., Ph.D.; Marcelo Gama de Abreu, M.D., M.Sc., Ph.D., D.E.S.A.
Tags: bi-level positive airway pressure, inspiration, lung, lung injuries, respiration
Anesthesiology March 2014, Vol.120, 673-682. doi:10.1097/ALN.0000000000000124
Lung [18F]fluorodeoxyglucose Uptake and Ventilation–Perfusion Mismatch in the Early Stage of Experimental Acute Smoke Inhalation Free
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Guido Musch, M.D.; Tilo Winkler, Ph.D.; R. Scott Harris, M.D.; Marcos F. Vidal Melo, M.D., Ph.D.; Tyler J. Wellman, Ph.D.; Nicolas de Prost, M.D., Ph.D.; Richard L. Kradin, M.D.; Jose G. Venegas, Ph.D.
Tags: lung, perfusion, smoke inhalation injury, ventilation-perfusion mismatching, smoke
Anesthesiology March 2014, Vol.120, 683-693. doi:10.1097/01.anes.0000435742.04859.e8
A Metabolomic Approach to the Pathogenesis of Ventilator-induced Lung Injury Free
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José L. Izquierdo-García, Ph.D.; Shama Naz, B.Sc.; Nicolás Nin, M.D.; Yeny Rojas, B.Sc.; Marcela Erazo, B.Sc.; Leticia Martínez-Caro, Ph.D.; Antonia García, Ph.D.; Marta de Paula, Ph.D.; Pilar Fernández-Segoviano, M.D.; Cristina Casals, Ph.D.; Andrés Esteban, M.D.; Jesús Ruíz-Cabello, Ph.D.; Coral Barbas, Ph.D.; José A. Lorente, M.D.
Tags: lung injury, ventilator-associated, metabolomics, metabolites, lung parenchyma
Anesthesiology March 2014, Vol.120, 694-702. doi:10.1097/ALN.0000000000000074

Pain Medicine Clinical Science

Ultrasound-guided Multilevel Paravertebral Blocks and Total Intravenous Anesthesia Improve the Quality of Recovery after Ambulatory Breast Tumor Resection Free
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Faraj W. Abdallah, M.D.; Pamela J. Morgan, M.D., F.R.C.P.C.; Tulin Cil, M.D., F.R.C.S.C.; Andrew McNaught, M.D., F.R.C.P.C.; Jaime M. Escallon, M.D., F.R.C.S.C.; John L. Semple, M.D., F.R.C.S.C.; Wei Wu, M.Sc.; Vincent W. Chan, M.D., F.R.C.P.C.
Tags: anesthesia, total intravenous, excision of malignant tumor of breast, opioids, paravertebral block, ultrasonography
Anesthesiology March 2014, Vol.120, 703-713. doi:10.1097/ALN.0000436117.52143.bc

Pain Medicine Basic Science

Novel Molecular Targets of Dezocine and Their Clinical Implications Free
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Renyu Liu, M.D., Ph.D.; Xi-Ping Huang, Ph.D.; Alexei Yeliseev, Ph.D.; Jin Xi, M.S.; Bryan L. Roth, M.D., Ph.D.
Tags: dezocine, serotonin transporter, opioid receptor, agonists
Anesthesiology March 2014, Vol.120, 714-723. doi:10.1097/ALN.0000000000000076
Lipid Rescue Reverses the Bupivacaine-induced Block of the Fast Na+ Current (INa) in Cardiomyocytes of the Rat Left Ventricle Free
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Michael Wagner, M.D., Ph.D.; York A. Zausig, D.E.A.A., M.D., Ph.D.; Stefan Ruf, M.S.; Elena Rudakova, Ph.D.; Michael Gruber, Ph.D.; Bernhard M. Graf, M.D., Ph.D.; Tilmann Volk, M.D., Ph.D.
Tags: bupivacaine, lipids, cardiac myocytes, left ventricle, mepivacaine
Anesthesiology March 2014, Vol.120, 724-736. doi:10.1097/ALN.0b013e3182a66d4d
Antihyperalgesic/Antinociceptive Effects of Ceftriaxone and Its Synergistic Interactions with Different Analgesics in Inflammatory Pain in Rodents Free
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Radica M. Stepanovic´-Petrovic´, Ph.D.; Ana M. Micov, B.Pharm.; Maja A. Tomic´, Ph.D.; Jovana M. Kovacˇevic´, B.Pharm.; Bogdan D. Boškovic´, Ph.D.
Tags: analgesics, ceftriaxone, inflammatory pain, hyperalgesia, rodentia
Anesthesiology March 2014, Vol.120, 737-750. doi:10.1097/ALN.0000435833.33515.ba

Education Images in Anesthesiology

Images in Anesthesiology: The Preoperative Stop/Go Sign Free
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Christopher W. Connor, M.D., Ph.D.; R. Mauricio Gonzalez, M.D.
Tags: preoperative care
Anesthesiology March 2014, Vol.120, 751. doi:10.1097/ALN.0b013e3182887547
Congenital Absence of the Sternum in a Neonate Free
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Premal M. Trivedi, M.D.; Ram Jagannathan, M.B.B.S.; Narasimhan Jagannathan, M.D.
Tags: newborn, sternum
Anesthesiology March 2014, Vol.120, 752. doi:10.1097/ALN.0b013e31828e8845

Education Clinical Concepts and Commentary

Perioperative Management of Patients with Mastocytosis Free
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Pascale Dewachter, M.D., Ph.D.; Mariana C. Castells, M.D., Ph.D.; David L. Hepner, M.D., M.P.H.; Claudie Mouton-Faivre, M.D.
Tags: mastocytosis, perioperative care, mast cell degranulation
Anesthesiology March 2014, Vol.120, 753-759. doi:10.1097/ALN.0000000000000031

Education Review Article

Anesthesia, Microcirculation, and Wound Repair in Aging Free
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Itay Bentov, M.D., Ph.D.; May J. Reed, M.D.
Tags: aging, microcirculation, wound healing
Anesthesiology March 2014, Vol.120, 760-772. doi:10.1097/ALN.0000000000000036

Education Mind to Mind

Hands Free
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Petramay Attard Cortis, M.D.
Tags: hand
Anesthesiology March 2014, Vol.120, 773. doi:10.1097/ALN.0000000000000035
Last Vigil Free
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Mary Hamilton Chestnut, M.S.N.
Anesthesiology March 2014, Vol.120, 774. doi:10.1097/ALN.0b013e3182a9af9d
Molding Metaphors: A Tribute to My Anesthesiology Mentor, F. C. Kumar, M.D. Free
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Edward S. Kosik, D.O.
Tags: mentors, metaphor
Anesthesiology March 2014, Vol.120, 775-778. doi:10.1097/ALN.0b013e31829e4b2b

Correspondence

Capnodynamic Estimation of Lung Volumes: Teething Issues of a Potential Early Warning System Free
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Yanzhi Zeng
Anesthesiology March 2014, Vol.120, 779. doi:10.1097/ALN.0000000000000104
In Reply Free