Newly Published
Correspondence  |   June 2020
Methadone and Chronic Pain: Reply
Author Notes
  • North Shore University HealthSystem, University of Chicago Pritzker School of Medicine, Chicago, Illinois. (G.S.M.). dgmurphy2@yahoo.com
  • Accepted for publication May 27, 2020.
    Accepted for publication May 27, 2020.×
Article Information
Correspondence
Correspondence   |   June 2020
Methadone and Chronic Pain: Reply
Anesthesiology Newly Published on June 17, 2020. doi:https://doi.org/10.1097/ALN.0000000000003433
Anesthesiology Newly Published on June 17, 2020. doi:https://doi.org/10.1097/ALN.0000000000003433
We thank Dr. Romanoff1  for his interest in our study of postoperative pain and analgesic requirements in the first year after intraoperative methadone for complex spine and cardiac surgery.2  Although the study was neither designed nor powered to determine the relationship between preoperative opioid use and postoperative analgesic requirements, we attempt to address his concerns with post hoc analyses.
Exclusion criteria for the study of intraoperative methadone for the prevention of postoperative pain in cardiac surgery patients included use of preoperative opioids or recent history of opioid abuse.3  Thus, preoperative opioid use could have no effect on their postoperative analgesic requirements.