Newly Published
Critical Care Medicine  |   February 2020
Does Iso-mechanical Power Lead to Iso-lung Damage?: An Experimental Study in a Porcine Model
Author Notes
  • From the Department of Anaesthesiology, Emergency and Intensive Care Medicine (F. Vassalli, I.P., F.R., E.D., D.J.A., H.G., M. Bonifazi, M. Busana, M.M.M., L.G., P.H., G.H., O.M., M.Q., L.G.), and Department of Experimental Animal Medicine (V.R.), University of Göttingen, Göttingen, Germany; Department of Adult Critical Care, Guy’s and St. Thomas’ NHS Foundation Trust, Health Centre for Human and Applied Physiological Sciences, King’s College London, London, United Kingdom (F. Vasques); Department of Pathology, Lodi General Hospital, Lodi, Italy (O.L.); and Regions Hospital and University of Minnesota, St. Paul, Minnesota (J.J.M.).
  • Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal’s Web site (www.anesthesiology.org).
    Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal’s Web site (www.anesthesiology.org).×
  • This was work was presented at S.M.A.R.T. Milano in Milan, Italy, May 10, 2019.
    This was work was presented at S.M.A.R.T. Milano in Milan, Italy, May 10, 2019.×
  • F.V. and I.P. contributed equally to this article.
    F.V. and I.P. contributed equally to this article.×
  • Submitted for publication August 21, 2019. Accepted for publication January 13, 2020.
    Submitted for publication August 21, 2019. Accepted for publication January 13, 2020.×
  • Correspondence: Address correspondence to Dr. Gattinoni: University of Göttingen, Department of Anaesthesiology, Robert-Koch-Straße, 40, 37075 Göttingen, Germany. gattinoniluciano@gmail.com. Information on purchasing reprints may be found at www.anesthesiology.org or on the masthead page at the beginning of this issue. Anesthesiology’s articles are made freely accessible to all readers, for personal use only, 6 months from the cover date of the issue.
Article Information
Critical Care Medicine / Critical Care / Respiratory System
Critical Care Medicine   |   February 2020
Does Iso-mechanical Power Lead to Iso-lung Damage?: An Experimental Study in a Porcine Model
Anesthesiology Newly Published on February 5, 2020. doi:https://doi.org/10.1097/ALN.0000000000003189
Anesthesiology Newly Published on February 5, 2020. doi:https://doi.org/10.1097/ALN.0000000000003189
Abstract

Editor’s Perspective:

What We Already Know about This Topic:

  • Ventilator-induced lung injury results from a complex interaction of physical variables involved in mechanical ventilation (tidal volume, respiratory rate [RR], positive end-expiratory pressure [PEEP], driving pressure, resistances, and flow).

  • Although each variable has been previously studied in isolation, their overall effects within the recent construct of mechanical power (the product of change of lung volume and absolute pressure) delivered to the lung per unit of time (J/min) remains controversial.

  • Previous animal studies have demonstrated mechanical power thresholds related to ventilator-induced lung injury, the adverse effects of high respiratory rate on low tidal volume ventilation in ventilator-induced lung injury, and the adverse effects of PEEP above a certain mechanical power threshold on ventilator-induced lung injury.

What This Article Tells Us That Is New:

  • The authors studied 42 healthy sedated pigs ventilated in the prone position for 48 h, controlling anesthetic level, hemodynamics, and temperature.

  • Three ventilatory strategies (high tidal volume, high RR, or high PEEP) were studied at two levels of mechanical power (15 or 30 J/min, regulated by manipulating the other component variables). Measurements included hemodynamics, lung mechanics, gas exchange, lung histology, and lung weight.

  • High PEEP, as expected, had the greatest adverse hemodynamic impact.

  • For all strategies, similar degrees of histologic lung injury and extravascular lung water accumulation occurred by 48 h, despite different time courses.

  • Paradoxically, a greater degree of alveolar edema occurred at lower mechanical power, perhaps explained by different hemodynamic patterns that favored or reduced extravascular fluid accumulation.

  • These data suggest that over time, the integrated effects resulting from high tidal volume, high RR, or high PEEP are more important than the direct and immediate consequence of any one of them alone. Ventilator-induced lung injury should be considered holistically in the context of whole-body physiology rather than as an isolated effect on the lung alone.

Background: Excessive tidal volume, respiratory rate, and positive end-expiratory pressure (PEEP) are all potential causes of ventilator-induced lung injury, and all contribute to a single variable: the mechanical power. The authors aimed to determine whether high tidal volume or high respiratory rate or high PEEP at iso-mechanical power produce similar or different ventilator-induced lung injury.

Methods: Three ventilatory strategies—high tidal volume (twice baseline functional residual capacity), high respiratory rate (40 bpm), and high PEEP (25 cm H2O)—were each applied at two levels of mechanical power (15 and 30 J/min) for 48 h in six groups of seven healthy female piglets (weight: 24.2 ± 2.0 kg, mean ± SD).

Results: At iso-mechanical power, the high tidal volume groups immediately and sharply increased plateau, driving pressure, stress, and strain, which all further deteriorated with time. In high respiratory rate groups, they changed minimally at the beginning, but steadily increased during the 48 h. In contrast, after a sudden huge increase, they decreased with time in the high PEEP groups. End-experiment specific lung elastance was 6.5 ± 1.7 cm H2O in high tidal volume groups, 10.1 ± 3.9 cm H2O in high respiratory rate groups, and 4.5 ± 0.9 cm H2O in high PEEP groups. Functional residual capacity decreased and extravascular lung water increased similarly in these three categories. Lung weight, wet-to-dry ratio, and histologic scores were similar, regardless of ventilatory strategies and power levels. However, the alveolar edema score was higher in the low power groups. High PEEP had the greatest impact on hemodynamics, leading to increased need for fluids. Adverse events (early mortality and pneumothorax) also occurred more frequently in the high PEEP groups.

Conclusions: Different ventilatory strategies, delivered at iso-power, led to similar anatomical lung injury. The different systemic consequences of high PEEP underline that ventilator-induced lung injury must be evaluated in the context of the whole body.