Newly Published
Correspondence  |   July 2019
Supplemental Oxygen and the Risk of Surgical Site Infection: Evidence of Compromised Data Requires Correction of Previously Published Meta-analysis
Author Notes
  • Department of Public Health, University of Zurich, Zürich, Switzerland (F.H.). frederique.lachmann@uzh.ch
  • Accepted for publication June 14, 2019.
    Accepted for publication June 14, 2019.×
Article Information
Correspondence
Correspondence   |   July 2019
Supplemental Oxygen and the Risk of Surgical Site Infection: Evidence of Compromised Data Requires Correction of Previously Published Meta-analysis
Anesthesiology Newly Published on July 19, 2019. doi:10.1097/ALN.0000000000002897
Anesthesiology Newly Published on July 19, 2019. doi:10.1097/ALN.0000000000002897
In a recent analysis investigating the scientific integrity of the work published by Schietroma et al., evidence was found for potential data fabrication in 38 trials reporting on a variety of perioperative interventions, including supplemental oxygen to reduce surgical site infections.1  While some of these studies have been retracted, others have now come under scrutiny and require further investigation. Major concerns were raised about the impact of these compromised data on the World Health Organization recommendations on surgical site infections,2  which included two trials published by Schietroma et al. The World Health Organization recommended the use of 80% inspired oxygen fraction. In contrast, two recently published meta-analyses found no argument in favor of high oxygen concentrations when trials by Schietroma et al. were excluded.1,3