Education  |   September 2019
Transfusion-related Acute Lung Injury in the Perioperative Patient
Author Notes
  • From the Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, Canada (M.J.M., J.W.S., W.M.K); Departments of Physiology and Anesthesia (M.J.M.), Pharmacology (J.W.S.), Laboratory Medicine–Pathobiology (C.C.-G.), Medicine–Division of Hematology (C.C.-G.), Anesthesia and Pain Management, University Health Network (K.K.), and Physiology and Surgery (W.M.K.), University of Toronto, Toronto, Canada (C.C.-G.); Sickkids Department of Anesthesia and Pain Medicine (M.J.M.), and Division of Hematology and Transfusion Medicine (R.K., J.W.S.), Lund University, Lund, Sweden; Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands (R.K.); Departments of Laboratory Hematology (Blood Transfusion Laboratory), Laboratory Medicine Program (C.C.-G.), and Medical Oncology and Hematology (C.C.-G.), University Health Network, Toronto, Canada (K.K.); Department of Clinical Pathology, Blood and Tissue Bank, Sunnybrook Health Sciences Centre, Toronto, Canada (C.C.-G.); and Institute of Physiology, Charité University Berlin, Berlin, Germany (W.M.K.).
  • This article is featured in “This Month in Anesthesiology,” page 1A.
    This article is featured in “This Month in Anesthesiology,” page 1A.×
  • This article has a video abstract.
    This article has a video abstract.×
  • For a downloadable PPT slide containing this article’s citation information, please visit https://anesthesiology.pubs.asahq.org/ss/downloadable_slide.aspx.
    For a downloadable PPT slide containing this article’s citation information, please visit https://anesthesiology.pubs.asahq.org/ss/downloadable_slide.aspx.×
  • Submitted for publication July 8, 2018. Accepted for publication February 6, 2019.
    Submitted for publication July 8, 2018. Accepted for publication February 6, 2019.×
  • Address correspondence to Dr. McVey: University of Toronto, Department of Anesthesiology, Sickkids Department of Anesthesiology and Pain Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada. mark.mcvey@utoronto.ca. Information on purchasing reprints may be found at www.anesthesiology.org or on the masthead page at the beginning of this issue. Anesthesiology’s articles are made freely accessible to all readers, for personal use only, 6 months from the cover date of the issue.
Article Information
Education / Review Article / Coagulation and Transfusion / Respiratory System
Education   |   September 2019
Transfusion-related Acute Lung Injury in the Perioperative Patient
Anesthesiology 9 2019, Vol.131, 693-715. doi:https://doi.org/10.1097/ALN.0000000000002687
Anesthesiology 9 2019, Vol.131, 693-715. doi:https://doi.org/10.1097/ALN.0000000000002687
Abstract

Transfusion-related acute lung injury is a leading cause of death associated with the use of blood products. Transfusion-related acute lung injury is a diagnosis of exclusion which can be difficult to identify during surgery amid the various physiologic and pathophysiologic changes associated with the perioperative period. As anesthesiologists supervise delivery of a large portion of inpatient prescribed blood products, and since the incidence of transfusion-related acute lung injury in the perioperative patient is higher than in nonsurgical patients, anesthesiologists need to consider transfusion-related acute lung injury in the perioperative setting, identify at-risk patients, recognize early signs of transfusion-related acute lung injury, and have established strategies for its prevention and treatment.