Correspondence  |   August 2016
Is It Time to Ask Different Questions about Aspiration?
Author Notes
  • Vanderbilt University, Monroe Carrell Jr. Children’s Hospital, Nashville, Tennessee.
  • (Accepted for publication April 20, 2016.)
    (Accepted for publication April 20, 2016.)×
Article Information
Correspondence   |   August 2016
Is It Time to Ask Different Questions about Aspiration?
Anesthesiology 8 2016, Vol.125, 425. doi:10.1097/ALN.0000000000001171
Anesthesiology 8 2016, Vol.125, 425. doi:10.1097/ALN.0000000000001171
To the Editor:
I read with interest the report by Beach et al.1  on the relationship between nil per os (NPO) time and major adverse events, with special attention to pulmonary aspiration. The authors conclude that NPO status is not an independent predictor of major complications.
As reported in other studies,2,3  the incidence of pulmonary aspiration was found to be quite low, with only 10 cases out of over 139,000 pediatric sedations collected between 2007 and 2011. It is noteworthy that NPO definitions within the Pediatric Sedation Research Consortium database (solids, 8 h; nonclear fluids, 6 h; and clears, 2 h) are out of step with the most recent American Society of Anesthesiologists guidelines from 2011,4  which recommend 6 h for formula/milk and “light” solids, 4 h for breast milk, and 2 h for clear liquids. Many Anesthesiology departments, including ours at Vanderbilt University, Nashville, Tennessee, have moved all solids to a fasting time of 6 h. By this measure, all of the 10 cases of aspiration would have been NPO appropriate with no episodes in those not NPO.
A look at Emergency Medicine literature5,6  shows a low incidence of aspiration even in nonfasted patients, many of whom are likely to be in pain. The American College of Emergency Physicians published a clinical policy in 20147  recommending that procedural sedation in the Emergency Room not be delayed solely due to NPO time. Unfortunately, the data presented in the study by Beach et al. are not broken down into elective versus emergent procedures. Additionally, the type of provider (emergency physician vs. other) cannot be used as a surrogate marker as emergency physicians often provide elective sedation services outside of the Emergency Room.
So where does this leave us? We are not suggesting, based on current evidence, that we reduce the NPO times for elective general anesthesia cases with planned airway instrumentation. But perhaps we should rethink the questions that we need answered regarding NPO in pediatric sedation.
What about emergent procedures without planned airway instrumentation? Many in emergency medicine would counter this question has already been answered. Can we quantify the risk of aspiration with planned airway instrumentation versus unplanned versus none at all? Does ketamine or dexmedetomidine, which preserve respiratory drive and airway tone better than propofol, offer a safer alternative in the nonfasted patient? All of these questions will be difficult to answer given the very low incidence of aspiration but we should certainly try.
Competing Interests
The author declares no competing interests.
Peter A. Chin, M.B.B.S., Vanderbilt University, Monroe Carrell Jr. Children’s Hospital, Nashville, Tennessee.
Beach, ML, Cohen, DM, Gallagher, SM, Cravero, JP Major adverse events and relationship to nil per os status in pediatric sedation/anesthesia outside the operating room: A report of the Pediatric Sedation Research Consortium.. Anesthesiology. (2016). 124 80–8 [Article] [PubMed]
Walker, RW Pulmonary aspiration in pediatric anesthetic practice in the UK: A prospective survey of specialist pediatric centers over a one-year period.. Paediatr Anaesth. (2013). 23 702–11 [Article] [PubMed]
Kluger, MT, Short, TG Aspiration during anaesthesia: A review of 133 cases from the Australian Anaesthetic Incident Monitoring Study (AIMS).. Anaesthesia. (1999). 54 19–26 [Article] [PubMed]
American Society of Anesthesiologists Committee, Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: Application to healthy patients undergoing elective procedures: An updated report by the American Society of Anesthesiologists Committee on Standards and Practice Parameters.. Anesthesiology. (2011). 114 495–511 [Article] [PubMed]
Agrawal, D, Manzi, SF, Gupta, R, Krauss, B Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department.. Ann Emerg Med. (2003). 42 636–46 [Article] [PubMed]
Roback, MG, Bajaj, L, Wathen, JE, Bothner, J Preprocedural fasting and adverse events in procedural sedation and analgesia in a pediatric emergency department: Are they related?. Ann Emerg Med. (2004). 44 454–9 [Article] [PubMed]
Godwin, SA, Burton, JH, Gerardo, CJ, Hatten, BW, Mace, SE, Silvers, SM, Fesmire, FM American College of Emergency Physicians, Clinical policy: Procedural sedation and analgesia in the emergency department.. Ann Emerg Med. (2014). 63 247–58.e18 [Article] [PubMed]