From the Brigham and Women’s Hospital, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Boston, Massachusetts (J.D.M., M.H., S.K.S., S.C.B.); Department of Genetics, Harvard Medical School, Boston, Massachusetts (D.C.C., D.M., J.G., E.M., S.R.D., J.G.S.); Harvard Medical School, Boston, Massachusetts (G.L.); Northwest Anesthesia, Abbott Northwestern Hospital and Minneapolis Heart Institute, Minneapolis, Minnesota (T.E.P.); Department of Anesthesiology, University of Texas Southwestern Medical Center, Dallas, Texas (A.A.F.); Howard Hughes Medical Institute, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts (C.E.S.); and Brigham and Women’s Hospital, Division of Cardiac Surgery, Department of Surgery, Harvard Medical School, Boston, Massachusetts (S.F.A.).
Corresponding article on page 486.
Corresponding article on page 486.
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Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal’s Web site (
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The last two authors contributed equally to this work.
The last two authors contributed equally to this work.
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Submitted for publication March 1, 2014. Accepted for publication October 20, 2014.
Submitted for publication March 1, 2014. Accepted for publication October 20, 2014.
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Address correspondence to Dr. Muehlschlegel: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, CWN L1, 75 Francis Street, Boston, Massachusetts 02115.
jmuehlschlegel@partners.org. Information on purchasing reprints may be found at
www.anesthesiology.org or on the masthead page at the beginning of this issue. Anesthesiology’s articles are made freely accessible to all readers, for personal use only, 6 months from the cover date of the issue.