Newly Published
Perioperative Medicine  |   May 2019
Days Alive and Out of Hospital: Validation of a Patient-centered Outcome for Perioperative Medicine
Author Notes
  • From the Department of Anesthesia and Pain Management, Toronto General Hospital (A.J., D.N.W.); the Department of Anesthesia, University of Toronto (A.J., D.N.W.); the Institute for Clinical Evaluative Sciences (A.J., P.C.A., D.N.W.); the Toronto General Hospital Research Institute (A.J.); and the Li Ka Shing Knowledge Institute, St. Michael’s Hospital (D.N.W.), Toronto, Ontario, Canada
  • Submitted for publication November 30, 2018. Accepted for publication February 22, 2019.
    Submitted for publication November 30, 2018. Accepted for publication February 22, 2019.×
  • Correspondence: Address correspondence to Dr. Jerath: Department of Anesthesia, Sunnybrook Health Sciences Centre, M3-200, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5. Angela.Jerath@mail.utoronto.ca. Information on purchasing reprints may be found at www.anesthesiology.org or on the masthead page at the beginning of this issue. Anesthesiology’s articles are made freely accessible to all readers, for personal use only, 6 months from the cover date of the issue.
Article Information
Perioperative Medicine / Cardiovascular Anesthesia / Central and Peripheral Nervous Systems / Gastrointestinal and Hepatic Systems / Renal and Urinary Systems / Electrolyte Balance / Quality Improvement
Perioperative Medicine   |   May 2019
Days Alive and Out of Hospital: Validation of a Patient-centered Outcome for Perioperative Medicine
Anesthesiology Newly Published on May 3, 2019. doi:10.1097/ALN.0000000000002701
Anesthesiology Newly Published on May 3, 2019. doi:10.1097/ALN.0000000000002701
Abstract

Editor’s Perspective:

What We Already Know:

  • Days alive and out of hospital is an easily obtained patient-centered outcome

What This Article Tells Us That Is New:

  • Days alive and out of hospital was associated with patient-level factors including comorbidities, advanced age, and complications, but not less relevant hospital-level factors

  • It appears to be a useful measure of surgical impact

Background: Days alive and out of hospital is a potentially useful patient-centered quality measure for perioperative care in adult surgical patients. However, there has been very limited prior validation of this endpoint with respect to its ability to capture differences in patient-level risk factor profiles and longer-term postoperative outcomes. The main objective of this study was assessment of the feasibility and validity of days alive and out of hospital as a patient-centered outcome for perioperative medicine.

Methods: The authors evaluated 540,072 adults undergoing 1 of 12 major elective noncardiac surgical procedures between 2006 to 2014. Primary outcome was days alive and out of hospital at 30 days, secondary outcomes were days alive and out of hospital at 90 days and 180 days. Unadjusted and risk-adjusted adjusted analyses were used to determine the association of days alive and out of hospital with patient-, surgery-, and hospital-level characteristics. Patients with days alive and out of hospital at 30 days values less than the tenth percentile were also classified as having poor days alive and out of hospital at 30 days. The authors then determined the association of poor days alive and out of hospital at 30 days with in-hospital complications, poor days alive and out of hospital at 90 days (less than the tenth percentile), and poor days alive and out of hospital at 180 days (less than the tenth percentile).

Results: Overall median (interquartile range) days alive and out of hospital at 30, 90, and 180 days were 26 (24 to 27), 86 (84 to 87), and 176 (173 to 177) days, respectively. Median days alive and out of hospital at 30 days was highest for hysterectomy and endovascular aortic aneurysm repair (27 days) and lowest for upper gastrointestinal surgery (22 days). Days alive and out of hospital at 30 days was associated with clinically sensible patient-level factors (comorbidities, advanced age, postoperative complications), but not measured hospital-level factors (academic status, bed size). Of patients with good days alive and out of hospital at 30 days, 477,163 of 486,087 (98%) and 470,093 of 486,087 (97%) remained within this group (greater than the tenth percentile) at days alive and out of hospital at 90 and 180 days.

Conclusions: Days alive and out of hospital is a feasibly measured patient-centered outcome that is associated with clinically sensible patient characteristics, surgical complexity, in-hospital complications, and longer-term outcomes. Days alive and out of hospital forms a novel patient-centered outcome for future clinical trials and observational studies for adult surgical patients.