Newly Published
Editorial Views  |   December 2018
Pounds of Prevention but Only Ounces of Cure: The Need for More Research on the Treatment of Postoperative Nausea and Vomiting
Author Notes
  • From the Department of Anaesthesia and Pain Medicine, Royal Melbourne Hospital, Melbourne, Australia (J.N.D., K.L.); Royal Melbourne Hospital Clinical School (J.N.D.), Centre for Integrated Critical Care Medicine (J.N.D., K.L.), and Department of Pharmacology and Therapeutics (K.L.), Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia; and Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (K.L.).
  • Accepted for publication October 31, 2018.
    Accepted for publication October 31, 2018.×
  • Correspondence: Address correspondence to Dr. Leslie: kate.leslie@mh.org.au
Article Information
Editorial Views / Gastrointestinal and Hepatic Systems / Pharmacology
Editorial Views   |   December 2018
Pounds of Prevention but Only Ounces of Cure: The Need for More Research on the Treatment of Postoperative Nausea and Vomiting
Anesthesiology Newly Published on December 21, 2018. doi:10.1097/ALN.0000000000002536
Anesthesiology Newly Published on December 21, 2018. doi:10.1097/ALN.0000000000002536
Surprisingly, despite a plethora of trials examining postoperative nausea and vomiting prophylaxis in a variety of patients, surgeries, drug combinations, and doses, there has been very little research assessing treatment. This is especially amazing given the incidence of postoperative nausea and vomiting in patients who have not received prophylaxis (10 to 80% depending on risk) and the requirement for “rescue” after failed prophylaxis (up to 30% in high-risk patients).1  Given the global volume of surgery, estimated at more than 300 million operations per annum, it is likely that, on any given day, hundreds of thousands of patients worldwide are vomiting, retching, or experiencing nausea after anesthesia. This has important implications for patients, anesthesiologists, and health services, and more research is urgently required.