Free
Erratum  |   July 2018
Free Fatty Acid Receptor G-protein–coupled Receptor 40 Mediates Lipid Emulsion-induced Cardioprotection: Erratum
Article Information
Erratum
Erratum   |   July 2018
Free Fatty Acid Receptor G-protein–coupled Receptor 40 Mediates Lipid Emulsion-induced Cardioprotection: Erratum
Anesthesiology 7 2018, Vol.129, 219. doi:10.1097/ALN.0000000000002255
Anesthesiology 7 2018, Vol.129, 219. doi:10.1097/ALN.0000000000002255
In the Online First article that published on April 3, 2018, the second paragraph of the Abstract Results section was erroneously published as the first paragraph of the article.
The Abstract Results section should read: “Results: G-protein–coupled receptor 40 is expressed in rodent hearts. GW1100 abolished lipid emulsion-induced cardioprotection against ischemia/reperfusion in mice because rate pressure product and left ventricular developed pressure were lower than lipid emulsion alone (rate pressure product: 2,186 ± 1,783 [n = 7] vs. 11,607 ± 4,347 [n = 8]; left ventricular developed pressure: 22.6 ± 10.4 vs. 63.8 ± 20; P < 0.0001). Lipid emulsion + GW1100 also demonstrated reduced LV dP/dtmax and LV dP/dtmin (dP/dtmax = 749 ± 386 vs. 2,098 ± 792, P < 0.001; dP/dtmin = −443 ± 262 vs. −1,447 ± 546, P < 0.001).
In bupivacaine-induced cardiotoxicity rat model, GW1100 pretreatment had no significant effect on heart rate (HR) and ejection fraction after 30 min (HR: 302 ± 17 vs. 312 ± 38; ejection fraction: 69 ± 3% vs. 73 ± 4%). GW1100 pretreatment, however, prevented lipid-rescue, with no recovery after 10 min. In the control group, lipid emulsion improved HR (215 ± 16 at 10 min) and fully rescued left ventricle function at 10 min (ejection fraction = 67 ± 8%, fractional shortening = 38 ± 6%).”
The first paragraph of the article should read: “We and others1–5 have shown that Intralipid (lipid emulsion) protects the heart against ischemia/reperfusion injury in rodents both in vivo and ex vivo through activation of intracellular signaling machinery. Recently, the protective effect of postischemic administration of lipid emulsion before aortic cross-unclamping on reperfusion injury was found in patients undergoing cardiac surgery as determined by a decrease in biomarkers of myocardial injury (cardiac troponin T and creatine kinase MB).6 Lipid emulsion postconditioning represents a novel and clinically feasible cardioprotective strategy.”
The publisher regrets this error. The online version and PDF of the article have been corrected.
Reference
Reference
Umar, S, Li, J, Hannabass, K, Vaillancourt, M, Cunningham, CM, Moazeni, S, Mahajan, A, Eghbali, M Free fatty acid receptor G-protein–coupled receptor 40 mediates lipid emulsion-induced cardioprotection. Anesthesiology 2018; 129:154–62