Education  |   October 2018
Images in Anesthesiology: Persistent Pulmonary Interstitial Emphysema
Author Notes
  • From the Department of Anesthesiology and Critical Care, Children’s Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Address correspondence to Dr. Subramanyam: subramanyr@email.chop.edu
Article Information
Education / Images in Anesthesiology / Respiratory System
Education   |   October 2018
Images in Anesthesiology: Persistent Pulmonary Interstitial Emphysema
Anesthesiology 10 2018, Vol.129, 808. doi:10.1097/ALN.0000000000002251
Anesthesiology 10 2018, Vol.129, 808. doi:10.1097/ALN.0000000000002251
PERSISTENT pulmonary interstitial emphysema is collection of air in the pulmonary interstitial tissue outside normal air passages. This air accumulation leads to cystic air spaces with hyperinflation of one lung and a mediastinal shift with associated contralateral lung volume loss (chest radiograph, A; computed tomography scan, B). It is a rare pathology seen in preterm infants with respiratory distress syndrome who have been mechanically ventilated.1  Persistent pulmonary interstitial emphysema can occur in term infants and in those who have not been mechanically ventilated.
Persistent pulmonary interstitial emphysema manifests as localized or diffuse forms, the latter carrying a poor prognosis. Differential diagnosis includes cystic adenomatoid malformation, lobar emphysema, diaphragmatic hernia, or bronchogenic cyst.1  Nonsurgical management includes selective bronchial occlusion, selective ventilation, steroids and/or surfactant, and lateral decubitus positioning with the upper good lung receiving most of the ventilation as compared to the dependent pathologic lung.1,2  Extracorporeal membrane oxygenation has been used to ventilate patients while allowing lung healing. Indications for surgical intervention include: persistent respiratory distress, recurrent infection, pneumothorax, inability to wean from mechanical ventilation, and definitive diagnosis when there is concern for a more pathologic lesion.1