Editorial Views  |   June 2018
Neutrophils: A Therapeutic Target of Local Anesthetics?
Author Notes
  • From the Department of Anesthesia and Pain Medicine, Hospital for Sick Children, and Department of Anesthesia, University of Toronto, Toronto, Canada.
  • Corresponding article on page 1151.
    Corresponding article on page 1151.×
  • Accepted for publication February 27, 2018.
    Accepted for publication February 27, 2018.×
  • Address correspondence to Dr. Steinberg: benjamin.steinberg@mail.utoronto.ca
Article Information
Editorial Views / Pharmacology
Editorial Views   |   June 2018
Neutrophils: A Therapeutic Target of Local Anesthetics?
Anesthesiology 6 2018, Vol.128, 1060-1061. doi:10.1097/ALN.0000000000002205
Anesthesiology 6 2018, Vol.128, 1060-1061. doi:10.1097/ALN.0000000000002205
Local anesthetics are familiar to all anesthesiologists. They canonically inhibit the alpha subunits of voltage-gated sodium channels within electrically excitable tissues. The ability to diminish the propagation of electrical signals through neurons and cardiac muscle forms the basis of their use in regional anesthesia and their arrhythmogenic cardiac complications, respectively. Yet empiric data have long suggested that local anesthetics also have antiinflammatory and antiapoptotic effects.1  These observations have been corroborated in preclinical models including those focused on the immune response to ischemia-reperfusion injury,2  a common pathology across our perioperative and critical care patient populations. The extent to which local anesthetics provide beneficial antiinflammatory effects and whether voltage-gated sodium channels are bona fide therapeutic targets for antiinflammatory interventions are open and intriguing questions for clinicians and scientists alike. As such, the role of these channels in immune cells remains an active area of research.
First Page Preview
First page PDF preview
First page PDF preview ×
View Large