Correspondence  |   December 2017
What Is the Role of Cytokines during Ventilator-induced Lung Injury?
Author Notes
  • Louis Mourier Hospital, Colombes, France (D.D.). didier.dreyfuss@aphp.fr
  • (Accepted for publication September 20, 2017.)
    (Accepted for publication September 20, 2017.)×
Article Information
Correspondence
Correspondence   |   December 2017
What Is the Role of Cytokines during Ventilator-induced Lung Injury?
Anesthesiology 12 2017, Vol.127, 1041-1042. doi:10.1097/ALN.0000000000001934
Anesthesiology 12 2017, Vol.127, 1041-1042. doi:10.1097/ALN.0000000000001934
We are pleased that Lex and Uhlig1  come to the same conclusion we published more than 15 yr ago,2  that the role of inflammatory cytokines is minor (if there is indeed any role at all) during ventilator-induced lung injury (VILI). However, we and Dr. Uhlig have had different perspectives on that matter for years. Indeed, in response to an article we wrote on the role of cytokines during VILI,3  Uhlig did not agree with our contention that cytokine secretion by the lungs is a by-product without physiologic significance. In contrast, he emphasized the importance of cytokine mediators in the pathogenesis of VILI.4 
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