Correspondence  |   November 2017
Amendments and Corrections to Mattusch et al. (Anesthesiology 2015; 122[5]:1047–59), “Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments”
Author Notes
  • Klinikum rechts der Isar, Technical University Munich, Munich, Germany (S.K.). s.kratzer@tum.de
  • (Accepted for publication July 12, 2017.)
    (Accepted for publication July 12, 2017.)×
Article Information
Correspondence
Correspondence   |   November 2017
Amendments and Corrections to Mattusch et al. (Anesthesiology 2015; 122[5]:1047–59), “Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments”
Anesthesiology 11 2017, Vol.127, 905-910. doi:10.1097/ALN.0000000000001830
Anesthesiology 11 2017, Vol.127, 905-910. doi:10.1097/ALN.0000000000001830
We previously reported that the anesthetic xenon impairs hyperpolarization-activated, cyclic nucleotide-gated cation channel type 2 (HCN2) function and thalamocortical signal propagation in murine thalamocortical slices, and supported by in vivo data, we discussed these findings as hypothetical mechanisms that might contribute to the anesthetic property of xenon.1  Subsequent to this publication, concerns were expressed to the Editor-in-Chief of the journal regarding part of the methodology, as well as the validity of the interpretation of our observations. In that correspondence, the following putative limitations of the in vitro and in vivo data were expressed:
Within the course of the ensuing communications, discrepancies between the methods employed and their description in the original article were also identified. For this we are indeed grateful, and these mistakes have also been corrected below. These issues prompted the Editor-in-Chief to request that we clarify the methodologic approach used in our original publication and suggested performing additional experiments to confirm that the effects observed were indeed exclusively due to xenon. We thank the Editor-in-Chief for the opportunity to address those concerns here.
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