Newly Published
Review Article  |   September 2017
Malignant Hyperthermia in the Post-Genomics Era: New Perspectives on an Old Concept
Author Notes
  • From the Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada (S.R., N.K.); and the Department of Anaesthesia, University of Leeds, Leeds, United Kingdom (P.M.H.).
  • Submitted for publication April 10, 2017. Accepted for publication June 26, 2017.
    Submitted for publication April 10, 2017. Accepted for publication June 26, 2017.×
  • Acknowledgments: The authors are grateful to Alexander Kraev, Ph.D., for his assistance in the design of the figure.
    Acknowledgments: The authors are grateful to Alexander Kraev, Ph.D., for his assistance in the design of the figure.×
  • Research Support: Supported by a merit award from Department of Anesthesia, University of Toronto, Canada (to Dr. Riazi) and National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health grant No. P01 AR052354 (to Dr. Hopkins).
    Research Support: Supported by a merit award from Department of Anesthesia, University of Toronto, Canada (to Dr. Riazi) and National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health grant No. P01 AR052354 (to Dr. Hopkins).×
  • Competing Interests: The authors declare no competing interests.
    Competing Interests: The authors declare no competing interests.×
  • Correspondence: Address correspondence to Dr. Riazi: University of Toronto, 323-200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada. Sheila.riazi@uhn.ca. Information on purchasing reprints may be found at www.anesthesiology.org or on the masthead page at the beginning of this issue. Anesthesiology’s articles are made freely accessible to all readers, for personal use only, 6 months from the cover date of the issue.
Article Information
Review Article / Patient Safety
Review Article   |   September 2017
Malignant Hyperthermia in the Post-Genomics Era: New Perspectives on an Old Concept
Anesthesiology Newly Published on September 14, 2017. doi:10.1097/ALN.0000000000001878
Anesthesiology Newly Published on September 14, 2017. doi:10.1097/ALN.0000000000001878
Abstract

This article reviews advancements in the genetics of malignant hyperthermia, new technologies and approaches for its diagnosis, and the existing limitations of genetic testing for malignant hyperthermia. It also reviews the various RYR1-related disorders and phenotypes, such as myopathies, exertional rhabdomyolysis, and bleeding disorders, and examines the connection between these disorders and malignant hyperthermia.