Editorial Views  |   September 2017
Tranexamic Acid: What Is Known and Unknown, and Where Do We Go From Here?
Author Notes
  • From the Department of Anesthesiology, Perioperative and Pain Medicine, Pharmacokinetics Laboratory, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts (S.M.G.); and Department of Anesthesiology/Critical Care Medicine, Johns Hopkins Health System Blood Management Program, The Johns Hopkins Medical Institutions, Baltimore, Maryland (S.M.F.).
  • This article has been selected for the Anesthesiology CME Program. Learning objectives and disclosure and ordering information can be found in the CME section at the front of this issue.
    This article has been selected for the Anesthesiology CME Program. Learning objectives and disclosure and ordering information can be found in the CME section at the front of this issue.×
  • Corresponding article on page 413.
    Corresponding article on page 413.×
  • Accepted for publication May 8, 2017.
    Accepted for publication May 8, 2017.×
  • Address correspondence to Dr. Frank: sfrank3@jhmi.edu
Article Information
Editorial Views / Central and Peripheral Nervous Systems / Coagulation and Transfusion / Hematologic System / Obstetric Anesthesia / Pharmacology / Practice Management
Editorial Views   |   September 2017
Tranexamic Acid: What Is Known and Unknown, and Where Do We Go From Here?
Anesthesiology 9 2017, Vol.127, 405-407. doi:10.1097/ALN.0000000000001788
Anesthesiology 9 2017, Vol.127, 405-407. doi:10.1097/ALN.0000000000001788
ANESTHESIOLOGISTS are experts at drug dosing, and we likely have more experience doing so than any other specialty in medicine. With anesthetic drugs such as fentanyl or propofol, we often dose by titrating to effect, which is sometimes more an art than a science. So what about drugs that are not titrated? Why do we give 2 g of cefazolin to virtually all adult patients, whether they are 40 or 120 kg? In fact, we give many such nontitratable drugs, tranexamic acid being one of them, for which the optimal dosing regimens have yet to be determined. Perhaps one dose does not fit all.
First Page Preview
First page PDF preview
First page PDF preview ×
View Large