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Education  |   May 2017
Images in Anesthesiology: Hypercoagulability during Resternotomy for Prosthetic Valve Endocarditis
Author Notes
  • From the Department of Anesthesia, American Anesthesiology of Minnesota (A.L.W., T.E.P.) and Minneapolis Heart Institute Cardiovascular Surgery (J.A.A., R.S.F.), Abbott Northwestern Hospital, Minneapolis, Minnesota.
  • Address correspondence to Dr. Wilkey: andrewwilkey@icloud.com
Article Information
Education / Images in Anesthesiology / Cardiovascular Anesthesia / Hematologic System
Education   |   May 2017
Images in Anesthesiology: Hypercoagulability during Resternotomy for Prosthetic Valve Endocarditis
Anesthesiology 5 2017, Vol.126, 978. doi:10.1097/ALN.0000000000001524
Anesthesiology 5 2017, Vol.126, 978. doi:10.1097/ALN.0000000000001524
APPROPRIATE management of coagulopathy during resternotomy for prosthetic valve endocarditis can reduce associated postoperative morbidity and mortality.1  While published literature suggests that endocarditis may be associated with overt hypercoagulability,2  sepsis is also associated with consumptive coagulopathy followed by pathologic bleeding.3  We present a series of intraoperative thromboelastograms from a patient undergoing replacement of an infected prosthetic aortic valve.
The thromboelastogram is a reaction curve representing changes in clot viscoelasticity over time. Maximum clot firmness (MCF) represents the maximal strength of the platelet and/or fibrin clot and can be both a sensitive and specific parameter when assessing hypercoagulability. When low, MCF can signify decreased platelet number or function, decreased fibrinogen or defects of fibrin polymerization, or low factor XIII activity. In these images, gray areas represent normal thromboelastogram tracings with normal (NL) MCF ranges for each identified within. Blue areas represent patient’s thromboelastogram tracings. MCF value for each assay appears horizontally to the right of each thromboelastogram. In this case, preincision thromboelastographic results demonstrate MCF in the extrinsic pathway (EXTEM), intrinsic pathway (INTEM), and fibrin clot (FIBTEM) assays outside the normal reference ranges, suggesting hypercoagulability (left figures). During rewarming on cardiopulmonary bypass (CPB), the thromboelastogram continues to demonstrate high MCF in the EXTEM, FIBTEM, and HEPTEM (intrinsic pathway with heparinase) assays, suggesting continued hypercoagulability, albeit less so, consistent with CPB-related clotting factor consumption (center figures). MCF continues to normalize after separation from CPB and protamine administration (right figures). Based on these results, the patient received no intraoperative blood product.
Competing Interests
The authors declare no competing interests.
References
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