Correspondence  |   February 2017
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Author Notes
  • Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands (L.H.L.R.).
  • (Accepted for publication October 5, 2016.)
    (Accepted for publication October 5, 2016.)×
Article Information
Correspondence   |   February 2017
In Reply
Anesthesiology 2 2017, Vol.126, 349-350. doi:10.1097/ALN.0000000000001438
Anesthesiology 2 2017, Vol.126, 349-350. doi:10.1097/ALN.0000000000001438
We would like to thank Mikhael et al. for their interest and comments related to our article1  and appreciate the opportunity to respond to the raised questions. Our study was by no means designed to prove the usefulness of cutaneous mitochondrial oxygen tension (mito-Po2) as physiologic transfusion trigger, but had the more modest goal of investigating the effects of hemodilution on this parameter. Because of the surprisingly useful behavior of mito-Po2 in our model, i.e., a steep decline when the individual critical hemoglobin threshold during hemodilution is neared, mito-Po2 seems a very promising parameter for use in transfusion medicine. Obviously, as also pointed out in the accompanying editorial,2  both technical and physiologic questions remain and the work has only just begun. In their letter, Mikhael et al. raise some of such remaining questions.
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