Newly Published
Perioperative Medicine  |   January 2017
Complications, Risk Factors, and Staffing Patterns for Noncardiac Surgery in Patients with Left Ventricular Assist Devices
Author Notes
  • From the Department of Anesthesiology (M.R.M., S.S., S.K., M.D.C., E.S.J., M.C.E.) and Department of Cardiac Surgery (F.D.P.), University of Michigan Health System, University of Michigan, Ann Arbor, Michigan.
  • Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal’s Web site (www.anesthesiology.org).
    Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal’s Web site (www.anesthesiology.org).×
  • The University of Michigan performs contract research with St. Jude (Pleasanton, California) and HeartWare (Framingham, Massachusetts).
    The University of Michigan performs contract research with St. Jude (Pleasanton, California) and HeartWare (Framingham, Massachusetts).×
  • Submitted for publication May 9, 2016. Accepted for publication November 15, 2016.
    Submitted for publication May 9, 2016. Accepted for publication November 15, 2016.×
  • Acknowledgments: The authors acknowledge Anik Sinha, M.S. (Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan) for his contributions in data acquisition and electronic search query programming for this project.
    Acknowledgments: The authors acknowledge Anik Sinha, M.S. (Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan) for his contributions in data acquisition and electronic search query programming for this project.×
  • Research Support: All work and partial funding attributed to the Department of Anesthesiology, University of Michigan Medical School (Ann Arbor, Michigan). The project described was supported in part by the National Center for Research Resources, Grant UL1RR024986, which is now at the National Center for Advancing Translational Sciences, Grant 2UL1TR000433 (Bethesda, Maryland). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
    Research Support: All work and partial funding attributed to the Department of Anesthesiology, University of Michigan Medical School (Ann Arbor, Michigan). The project described was supported in part by the National Center for Research Resources, Grant UL1RR024986, which is now at the National Center for Advancing Translational Sciences, Grant 2UL1TR000433 (Bethesda, Maryland). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.×
  • Competing Interests: The authors declare no competing interests.
    Competing Interests: The authors declare no competing interests.×
  • Correspondence: Address correspondence to Dr. Mathis: Department of Anesthesiology, University of Michigan 1H247 UH, SPC 5048, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109. mathism@med.umich.edu. Information on purchasing reprints may be found at www.anesthesiology.org or on the masthead page at the beginning of this issue. Anesthesiology’s articles are made freely accessible to all readers, for personal use only, 6 months from the cover date of the issue.
Article Information
Perioperative Medicine / Cardiovascular Anesthesia / Technology / Equipment / Monitoring
Perioperative Medicine   |   January 2017
Complications, Risk Factors, and Staffing Patterns for Noncardiac Surgery in Patients with Left Ventricular Assist Devices
Anesthesiology Newly Published on January 12, 2017. doi:10.1097/ALN.0000000000001488
Anesthesiology Newly Published on January 12, 2017. doi:10.1097/ALN.0000000000001488
Abstract

Background: Patients with left ventricular assist devices presenting for noncardiac surgery are increasingly commonplace; however, little is known about their outcomes. Accordingly, the authors sought to determine the frequency of complications, risk factors, and staffing patterns.

Methods: The authors performed a retrospective study at their academic tertiary care center, investigating all adult left ventricular assist device patients undergoing noncardiac surgery from 2006 to 2015. The authors described perioperative profiles of noncardiac surgery cases, including patient, left ventricular assist device, surgical case, and anesthetic characteristics, as well as staffing by cardiac/noncardiac anesthesiologists. Through univariate and multivariable analyses, the authors studied acute kidney injury as a primary outcome; secondary outcomes included elevated serum lactate dehydrogenase suggestive of left ventricular assist device thrombosis, intraoperative bleeding complication, and intraoperative hypotension. The authors additionally studied major perioperative complications and mortality.

Results: Two hundred and forty-six patients underwent 702 procedures. Of 607 index cases, 110 (18%) experienced postoperative acute kidney injury, and 16 (2.6%) had elevated lactate dehydrogenase. Of cases with complete blood pressure data, 176 (27%) experienced intraoperative hypotension. Bleeding complications occurred in 45 cases (6.4%). Thirteen (5.3%) patients died within 30 days of surgery. Independent risk factors associated with acute kidney injury included major surgical procedures (adjusted odds ratio, 4.4; 95% CI, 1.1 to 17.3; P = 0.03) and cases prompting invasive arterial line monitoring (adjusted odds ratio, 3.6; 95% CI, 1.3 to 10.3; P = 0.02) or preoperative fresh frozen plasma transfusion (adjusted odds ratio, 1.7; 95% CI, 1.1 to 2.8; P = 0.02).

Conclusions: Intraoperative hypotension and acute kidney injury were the most common complications in left ventricular assist device patients presenting for noncardiac surgery; perioperative management remains a challenge.