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Table of Contents  |   December 2016
Anesthesiology
Article Information
Table of Contents
Table of Contents   |   December 2016
Anesthesiology
Anesthesiology 12 2016, Vol.125, A13-A17. doi:10.1097/ALN.0000000000001463
Anesthesiology 12 2016, Vol.125, A13-A17. doi:10.1097/ALN.0000000000001463
ON THE COVER:
γ-Aminobutyric acid type A (GABAA) receptors mediate important effects of intravenous general anesthetics. Prior studies have defined the detailed molecular structure of this voltage-gated ion channel and how general anesthetics like propofol and etomidate bind to these channels. In this issue of Anesthesiology, Nourmahnad et al. use mutation-based strategies combined with voltage-clamp electrophysiology to identify distinct binding sites for four intravenous anesthetics.
  • Nourmahnad et al.: Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site, p. 1144

  • Jenkins and Jenkins: Anesthetic–Receptor Relationship Status: It’s Complicated, p. 1088