Special Articles  |   November 2016
Preclinical Pain Research: Can We Do Better?
Author Notes
  • From the Department of Anesthesiology, Veterans Affairs Palo Alto Health Care System, Palo Alto, California; and Department of Anesthesiology, Pain and Perioperative Medicine, Stanford University School of Medicine, Stanford, California.
  • This article is featured in "This Month in Anesthesiology," page 1A.
    This article is featured in "This Month in Anesthesiology," page 1A.×
  • Submitted for publication July 7, 2016. Accepted for publication August 8, 2016.
    Submitted for publication July 7, 2016. Accepted for publication August 8, 2016.×
  • Address correspondence to Dr. Clark: Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, California 94304. djclark@stanford.edu. Information on purchasing reprints may be found at www.anesthesiology.org or on the masthead page at the beginning of this issue. Anesthesiology’s articles are made freely accessible to all readers, for personal use only, 6 months from the cover date of the issue.
Article Information
Special Articles / Pain Medicine
Special Articles   |   November 2016
Preclinical Pain Research: Can We Do Better?
Anesthesiology 11 2016, Vol.125, 846-849. doi:10.1097/ALN.0000000000001340
Anesthesiology 11 2016, Vol.125, 846-849. doi:10.1097/ALN.0000000000001340
Abstract

Regrettably, the list of unique analgesic tools has expanded very slowly during the past few decades. Many very promising drugs have failed once tested in clinical populations, and the associated costs of these translational failures have been extremely high. Part of this problem can be traced to the ways we select and use preclinical tools and perhaps to the way we report our findings. We are beginning to reevaluate our selection of animal models and the methods we use to measure pain-related responses in these animals. In addition, many journals now require a clear statement of the experimental hypothesis, the details of the experimental methods, a description of the statistical approach to analyzing the data, and the disclosure of conflicts of interest. These new practices pose challenges to laboratory-based research groups. However, a more rigorous approach to preclinical investigations may be necessary for the successful development of new analgesics.