Correspondence  |   September 2016
Proof of Concept—How to Bridge Proof with Concept and Linked to Reality
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Article Information
Correspondence
Correspondence   |   September 2016
Proof of Concept—How to Bridge Proof with Concept and Linked to Reality
Anesthesiology 9 2016, Vol.125, 602-604. doi:10.1097/ALN.0000000000001205
Anesthesiology 9 2016, Vol.125, 602-604. doi:10.1097/ALN.0000000000001205
We read the article by Avramescu et al. published in Anesthesiology with great interest.1  The authors investigated the effect of interleukin-1β on the γ-aminobutyric acid (GABA) inhibitory currents in hippocampal and cortical neurons after exposure to etomidate or isoflurane in vitro. They arrived at their findings with the use of a mice model of sepsis consisting of intraperitoneal lipopolysaccharide injection. They were able to show some interaction between lipopolysaccharide and some, not all, measures of behavioral effectiveness of two anesthetics. Overall, results described seem to offer insight on the potential relationship between inflammation and the amount of anesthetic needed in mouse models to achieve the desired anesthesia. In conclusion, the authors extrapolated the results of their study to clinically relevant scenarios of sepsis.
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