Jennifer Shih, Laura D. V. May, Heidi E. Gonzalez, Elaine W. Lee, Rehan S. Alvi, Jeffrey W. Sall, Vinuta Rau, Philip E. Bickler, Gopal R. Lalchandani, Marianna Yusupova, Elliott Woodward, Heejae Kang, Alan J. Wilk, Colleen M. Carlston, Mortay V. Mendoza, Jeremy N. Guggenheim, Maximilian Schaefer, Allison M. Rowe, Greg Stratmann; Delayed Environmental Enrichment Reverses Sevoflurane-induced Memory Impairment in Rats. Anesthesiology 2012;116(3):586-602. doi: 10.1097/ALN.0b013e318247564d.
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© 2018 American Society of Anesthesiologists
Potent volatile anesthetic agents produce long-term neurocognitive impairment in developing rodents
Sevoflurane is the preferred volatile agent in pediatric anesthesia
Environmental enrichment improves brain function
Sevoflurane, with or without tissue injury, causes long-term impairment in spatial short-term memory in infantile rats that is unaffected by tissue injury
Delayed environmental enrichment treats this long-term neurocognitive impairment
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