Free
Correspondence  |   February 1995
Reply: More on Barbiturate-related Hyperalgesia
Author Notes
  • S. Hugo, M.B.Ch.B., D.A., Registrar, A. P. J. Lake, B.Sc., M.B.B.S., F.F.A.R.C.S., Consultant, B. A. Cooledge, R.G.N., Clinical Nurse Specialist, Department of Anaesthesia, Glan Clwyd District General Hospital, Bodelwyddan, Rhyl, Clwyd LL18 5UJ United Kingdom.
Article Information
Correspondence
Correspondence   |   February 1995
Reply: More on Barbiturate-related Hyperalgesia
Anesthesiology 2 1995, Vol.82, 601. doi:
Anesthesiology 2 1995, Vol.82, 601. doi:
In Reply:—Publication of results of a large study in the form of a letter necessarily sacrifices clarity for brevity. We were limited by the resources of our district hospital and in study design by an uncertainty as to the timing of magnitude of effect, if any, but consider our conclusion that barbiturate hyperalgesia appears to have little clinical relevance to be quite justified.
In our final paragraph, we suggested that a further study should concentrate on the 0–4-hr period, when, for example, the effect of residual barbiturate sedation may be operative, and a new design can incorporate the three factors listed by the authors.
We look forward with interest to the results of such a definitive study.
S. Hugo, M.B.Ch.B., D.A.; Registrar; A. P. J. Lake, B.Sc., M.B.B.S., F.F.A.R.C.S.; Consultant; B. A. Cooledge, R.G.N.; Clinical Nurse Specialist; Department of Anaesthesia; Glan Clwyd District General Hospital; Bodelwyddan; Rhyl; Clwyd LL18 5UJ United Kingdom.
(Accepted for publication November 3, 1994.)