Correspondence  |   February 1998
Desflurane Degradation to Carbon Monoxide
Author Notes
  • Worldwide Product Manager, Sodasorb Absorbents, GRACE Container Products, W. R. Grace & Company, 55 Hayden Avenue, Lexington, Massachusetts 02173.
Article Information
Correspondence   |   February 1998
Desflurane Degradation to Carbon Monoxide
Anesthesiology 2 1998, Vol.88, 547. doi:
Anesthesiology 2 1998, Vol.88, 547. doi:
To the Editor:-As manufacturers of Sodalime based CO2absorbents, Grace takes issue with the recommendation (Desflurane Degradation to Carbon Monoxide, Anesthesiology, 1997; 86:1061–5) that a practitioner consider the rehydration of Baralyme CO2absorbent when dehydration of the absorbent is suspected.
We caution against the adulteration of these products because it is known that moisture content in excess of the USP standards will decrease CO2absorption efficiency. Current moisture content standards as prescribed in the United States Pharmacopoeia-National Formulary for Barium Hydroxide Lime and Soda Lime are 11–16% and 12–19%, respectively. We believe that attempts by practitioners to add moisture to the absorbent, without a predetermination of the existing moisture level, or in disregard of the USP standards could lead to agglomeration of the absorbent granules in addition to a significant loss in absorption capacity if moisture content standards are exceeded.
As Baxter and Kharasch point out in the article, dehydration of the absorbent is often reported when the anesthesia equipment has been idle for extended periods, and it is frequently associated with high gas flows through the absorbent bed during idle periods.
The presumption in the article that a practitioner can use rehydration as a cost-effective alternative to discarding the absorbent, rather than the FDA recommended procedure of discarding the absorbent whenever dehydration is suspected, seems not to address the root cause of dehydration-the practice of allowing extended high gas flows through the absorbent bed during idle equipment periods-and further compounds the issue by introducing a second questionable practice-uncontrolled moisture addition.
W. R. Grace stands by its recommendation to always replace any CO2absorbent whenever there is suspicion that absorbent moisture loss has occurred. To do otherwise may pose patient safety hazards as a result of loss of CO2absorption efficiency, disregards the FDA's recommended procedure of discarding absorbent when dehydration is suspected, and may result in inadvertent use of absorbent containing moisture levels in excess of those prescribed by the USP.
James F. McGovern
Worldwide Product Manager; Sodasorb Absorbents; GRACE Container Products; W. R. Grace & Company; 55 Hayden Avenue; Lexington, Massachusetts 02173
(Accepted for publication September 10, 1997.)