Free
Correspondence  |   June 2002
Which Formulation of Propofol was Used?
Author Notes
  • Anesthesia Department, New Britain General Hospital, New Britain, Connecticut.
Article Information
Correspondence
Correspondence   |   June 2002
Which Formulation of Propofol was Used?
Anesthesiology 6 2002, Vol.96, 1530. doi:
Anesthesiology 6 2002, Vol.96, 1530. doi:
In Reply:—
I appreciate Dr. Matsumura's interest. The propofol formulation in my case did not contain metabisulfite.
Regarding the patient's depth of anesthesia, I would like to point out that despite thorough preoxygenation, she desaturated before any airway instrumentation, suggesting that bronchospasm was evolving before intubation. She had received 1 mg midazolam and 50 μg fentanyl and approximately 2.5 mg/kg propofol for induction. I doubt that light anesthesia caused her event.
The philosopher David Hume believed that an effect could never be absolutely attributed to a given cause despite their temporal association. Although there were certainly other possible causes for the problems reported by myself and others, their association with rapacuronium, a newly released drug known to produce mild bronchospasm, made it necessary to report these events to the anesthesia community.