Correspondence  |   June 2004
Cerebrospinal Fluid Physiology and Cerebrospinal Fluid Drainage
Author Affiliations & Notes
  • Rajesh Mahajan, M.D.
  • Rahul Gupta, M.B.B.S.
  • * Acharya Shri Chander College of Medical Sciences, Jammu, India. ,
Article Information
Correspondence   |   June 2004
Cerebrospinal Fluid Physiology and Cerebrospinal Fluid Drainage
Anesthesiology 6 2004, Vol.100, 1620. doi:
Anesthesiology 6 2004, Vol.100, 1620. doi:
To the Editor:—  It was interesting to read the case report by Fleck et al.  1 suggesting an appropriate duration of cerebrospinal fluid drainage after thoracoabdominal aneurysm repair. However, toward the end of their discussion, the authors mention that draining 1,700 ml cerebrospinal fluid over 24 h is seven times greater than the normal 250 ml cerebrospinal fluid that is produced in the same period. Although it may be a minor point, cerebrospinal fluid is actually formed at the rate of 500–550 ml/24 h and not 250 ml, as mentioned by the authors. 2–5 
Fleck TM, Koinig H, Hutschala D, Wolner E, Grabenwoger M: Cerebrospinal fluid drainage after thoracoabdominal aortic aneurysm repair. Anesthesiology 2003; 99:1019–20
Guyton AC, Hall JE: Cerebral blood flow, the cerebrospinal fluid, and brain metabolism, Textbook of Medical Physiology, 10th edition. Edited by Guyton AC, Hall JE. Orlando, Florida, Harcourt, 2000, pp 709–17
Ganong WF: Circulation through special regions, Review of Medical Physiology, 20th edition. Edited by Ganong WF. Boston, McGraw Hill, 2002, pp 588–606
Sherwood L: The central nervous system, Human Physiology from Cells to Systems, 4th edition. Edited by Sherwood L. Australia, Brooks/Cale Thompson Learning, 2001, pp 122–72
Drummond JC, Patel PM: Cerebral physiology and the effects of anesthetics and techniques, Anesthesia, 5th edition. Editing by Miller RD. Philadelphia, Churchill Livingstone, 2000, pp 695–733