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Correspondence  |   March 2003
Does Vasopressin Infusion Improve the Outcome of Severe Septic-Shock without any Adverse Effects?
Author Affiliations & Notes
  • Tetsuya Iijima, M.D.
    *
  • *Yamanashi Medical University, Tamaho, Yamanashi, Japan.
Article Information
Correspondence
Correspondence   |   March 2003
Does Vasopressin Infusion Improve the Outcome of Severe Septic-Shock without any Adverse Effects?
Anesthesiology 3 2003, Vol.98, 793. doi:
Anesthesiology 3 2003, Vol.98, 793. doi:
To the Editor:—
We read with great interest the report by Patel et al.  on beneficial effects of short-term infusion of vasopressin for severe septic shock. 1 The authors reported that for 24 patients with severe septic shock, 4 h infusion of vasopressin spared norepinephrine to maintain mean arterial pressure and improved urine output and creatinine clearance compared with the control group (norepinephrine infusion) in a double-blinded, randomized, controlled fashion. We were impressed with the results showing that low-dose vasopressin therapy may increase survival of septic shock. However, there was no information about the outcome of their patients. To survive from severe septic shock, there may be a need for long-term vasopressin infusion to maintain stable cardiovascular status. Dunser et al.  demonstrates 72-h vasopressin infusion brings about a significant increase in liver enzymes and total bilirubin concentration and a significant decrease in platelet count. 2 
References
Patel BM, Chittock DR, Russell JA, Walley KR: Beneficial effects of short-term vasopressin infusion during severe septic shock. A nesthesiology 2002; 96: 576–82Patel, BM Chittock, DR Russell, JA Walley, KR
Dunser MW, Mayr AJ, Ulmer H, Ritsch N, Knotzer H, Pajk W, Luckner G, Mutz NJ, Hasibeder WR: The effects of vasopressin on systemic hemodynamics in catecholamine-resistant septic and postcardiotomy shock: a retrospective analysis. Anesth and Analg 2001; 93: 7–13Dunser, MW Mayr, AJ Ulmer, H Ritsch, N Knotzer, H Pajk, W Luckner, G Mutz, NJ Hasibeder, WR