Case Reports  |   December 2003
Ropivacaine-induced Cardiac Arrest after Peripheral Nerve Block: Successful Resuscitation
Author Affiliations & Notes
  • Pascal Chazalon, M.D.
  • Jean P. Tourtier, M.D.
  • Thierry Villevielle, M.D.
  • Didier Giraud, M.D.
  • Jean M. Saïssy, M.D.
  • Georges Mion, M.D.
  • Dan Benhamou, M.D.
  • * Physician Anesthesiologist, † Professor, Chief of Staff, Federation of Anesthesia and Intensive Care, Hôpital d'Instruction des Armées Bégin. ‡ Professor, Chief of Staff, Department of Anesthesiology, Hôpital d'Instruction des Armées du Val-de-Grâce, Paris, France. § Professor, Chief of Staff, Department of Anesthesiology, Centre Hospitalier Universitaire de Bicêtre, Le Kremlin-Bicêtre, France.
  • Received from the Federation of Anesthesia and Intensive Care, Hôpital d'Instruction des Armées Bégin, Saint-Mande, France.
Article Information
Case Reports
Case Reports   |   December 2003
Ropivacaine-induced Cardiac Arrest after Peripheral Nerve Block: Successful Resuscitation
Anesthesiology 12 2003, Vol.99, 1449-1451. doi:
Anesthesiology 12 2003, Vol.99, 1449-1451. doi:
ROPIVACAINE is an amide local anesthetic with a long duration of action that was developed because of the high risk of cardiac complications induced by bupivacaine. 1 Preclinical studies have confirmed its reduced systemic and cardiac toxicity as compared with bupivacaine, 2,3 and clinical studies have also been very reassuring regarding the risk of ropivacaine-induced systemic toxicity. 4,5 There have, however, been several case reports in which significant cardiac side effects have occurred, but in none of them did the cardiac abnormalities progress to cardiac arrest or death. 6 We report a clinical case in which cardiac arrest occurred, after neurologic complications, during lower limb regional anesthesia using ropivacaine, but resuscitation was successful.
Case Report
A 66-yr-old woman (height, 150 cm; weight, 45 kg; American Society of Anesthesiologists physical status II) was scheduled for right hallux valgus surgery with the patient receiving regional anesthesia. The patient had a single kidney, but her medical history disclosed no renal dysfunction. She presented with no cardiac, neurologic, or pulmonary alterations. Her unique treatment was hormone replacement therapy. She had already undergone left hallux valgus surgical treatment 3 months ago in the same institution. Although regional anesthesia had failed for the first procedure and general anesthesia had to be used, the patient agreed that regional anesthesia be tried again. Hydroxyzine (50 mg) was given as premedication 2 h before the procedure. The regional block was performed in the preanesthetic room while the patient was monitored using three-lead electrocardiography, noninvasive blood pressure determination, and pulse oximetry. Her initial blood pressure and heart rate were 155/70 mmHg and 92 beats/min, respectively. An 18-gauge venous catheter was placed in her left forearm and infused with lactated Ringer's solution. Midazolam (2 mg) was given before the event because of anxiety. Once administration of oxygen (3 l/min via a facemask) was started, arterial oxygen saturation increased from 98% to 100%. After skin disinfection and local anesthesia with 2 ml lidocaine (1%), the patient was placed in the ventral decubitus, and the sciatic nerve was located in the popliteal fossa using nerve stimulation (STIMUPLEX-DIG; B. Braun Melsugen AG, Germany). A tibial nerve response was obtained at 0.4 mA (lowest intensity), and 25 ml ropivacaine (0.75%) was slowly injected (time 0) after a negative aspiration test, disappearance of the motor response after injection of 1 ml, and absence of pain and/or paresthesia. A popliteal catheter was placed for postoperative analgesia. Thirty minutes later, the saphenous nerve was subcutaneously infiltrated with 5 ml ropivacaine (0.75%), 7 and two additional injections were given at the ankle because of inadequate efficacy of the block: 4 ml ropivacaine (0.75%) was injected in the tibial nerve using nerve stimulation (0.4 mA), and 6 ml ropivacaine (0.75%) was infiltrated subcutaneously in the superficial and deep peroneal nerves. The total dose of ropivacaine was 300 mg.
This article is accompanied by an Editorial View. Please see: Polley LS, Santos AC: Cardiac Arrest following Regional Anesthesia with Ropivacaine: Here We Go Again! Anesthesiology 2003; 99:1253–4.
Sixty minutes later, the patient became agitated and confused, which was followed by loss of consciousness and oculogyric movements. Intravenous midazolam (2 mg) was injected, and mask ventilation was started. Bradycardia (heart rate, <50 beats/min) with hypotension (blood pressure, 90/60 mmHg) progressively appeared. Although the patient received 6 mg ephedrine and 1 mg atropine, bradycardia worsened (heart rate, 30 beats/min), whereas the QRS complex became larger and progressed to asystolic cardiac arrest. Cardiac massage was started, and 6 mg ephedrine was injected. Thirty seconds later, effective cardiac and respiratory activities reappeared, and sinus tachycardia rhythm was recorded. The patient responded to stimulation, and oxygen administration was continued. At 70 min, glucose, electrolyte, and troponin plasma concentrations were normal, whereas the ropivacaine plasma concentration measured using gas chromatography was 1.88 mg/l. The surgical procedure was performed under regional anesthesia after the patient had awakened. The patient had no awareness of the incident, had no sequelae, and was informed.
Ropivacaine is an amino amide local anesthetic that differs from bupivacaine by the substitution of a propyl group for a butyl group on the nitrogen of the piperidine group. This substitution, which is associated with a lower lipid solubility and commercial release as a pure S  -enantiomer, confers to ropivacaine a neurologic and cardiac toxicity inferior to that of an equal dose of bupivacaine. 8,9 Greater safety is expected with use of large doses. In different studies, extremely high ropivacaine plasma concentrations after regional anesthesia (from 2 to 5.6 mg/l) were obtained without neurologic and cardiac toxicity. 4,5 Several accidents after ropivacaine use have, however, been reported. Table 1summarizes previously reported cases in which total ropivacaine venous plasma concentrations were obtained. 6,10–18 These accidents were the consequence of direct intravascular injections (short onset) or secondary plasma absorption of an overdose (delayed clinical event). In the current case, cardiac arrest occurred. The absence of a neurologic or cardiac history, the time profile, and the symptoms observed suggest a ropivacaine-induced toxic accident. The total dose administered (i.e.  , 6.7 mg/kg) was definitely excessive. Although it is difficult to recommend a safe maximal dose because of interindividual variability, it is reasonable to accept a maximum ropivacaine dose of 3 mg/kg for an upper limb block and 4 mg/kg for a lower limb block. 19 The total ropivacaine plasma concentration measured 10 min after the toxic event was 1.88 mg/l and appeared to be low compared with those in the available literature (Table 1). This may suggest a particular sensitivity of the patient to local anesthetic toxicity, as has already been observed in ropivacaine toxicity studies. 2,3 Several healthy volunteers tolerated only low doses, and initial neurologic signs occurred at plasma concentrations (venous samples) between 0.5 and 1 mg/l; one patient tolerated a plasma concentration of 3.2 mg/l. 3 Alternatively, the apparently low plasma concentration of ropivacaine might be related to the long interval between injection and cardiac arrest, allowing time for redistribution from blood to tissue and binding to plasma proteins. 20 
Table 1. Previously Reported Cases of Severe Neurologic or Cardiac Adverse Effects Induced by Ropivacaine after Regional Anesthesia
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Table 1. Previously Reported Cases of Severe Neurologic or Cardiac Adverse Effects Induced by Ropivacaine after Regional Anesthesia
The incidence of ropivacaine-induced cardiovascular events has been described as 6.1 cases per 1,000,000 patients, compared with 8 cases of ropivacaine-induced neurologic convulsions per 1,000,000 patients. 21 In previously reported cases, cardiac complications during ropivacaine toxic accidents always followed severe neurologic signs (confusion and convulsions). In our case, however, only oculogyric movements were observed, possibly because the patient had received midazolam before the regional block.
In healthy volunteers, ropivacaine can impair conduction and myocardial contraction, but these events occur at plasma concentrations much higher than with bupivacaine, suggesting better tolerance and thus confirming findings of animal experiments. 2,3 Moreover, these effects are more rapidly reversible. During the only serious cardiac accident reported so far, ropivacaine was responsible for severe intraventricular and atrioventricular conduction defects, which led to severe bradycardia 6; the total ropivacaine plasma concentration was 3.6 mg/l (free concentration, 0.69 mg/l) 7 min after the accident, and the authors estimated the plasma concentration to be around 7.5 mg/l during the accident. A similar sequence of event mechanisms occurred in our patient and was associated with depression of myocardial contractility and cardiac arrest. As in the case reported by Ruetsch et al.  , 6 resuscitation was immediate and successful. No ventricular arrhythmias were observed. Although cardiopulmonary resuscitation was certainly facilitated by early treatment, the intrinsic lower cardiotoxicity (as compared with bupivacaine) certainly explains the outcome. 22 Moreover, the treatment was not only successful but also very simple, contrasting the rash of bupivacaine-associated cardiac arrest that is often very difficult to treat because it may require cardiopulmonary bypass. 23,24 
We report a case of cardiac arrest induced by ropivacaine overdose. Cardiorespiratory resuscitation was successful and easy to perform, substantiating previous data showing that ropivacaine is less cardiotoxic than bupivacaine.
Albright GA: Cardiac arrest following regional anesthesia with etidocaine and bupivacaine. A nesthesiology 1979; 51: 285–7Albright, GA
Scott DB, Lee A, Fagan D, Bowler GMR, Bloomfield P, Lundh R: Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth Analg 1989; 69: 563–9Scott, DB Lee, A Fagan, D Bowler, GMR Bloomfield, P Lundh, R
Knudsen K, Beckman Suurküla M, Blomberg S, Sjövall J, Edvarsson N: Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth 1997; 78: 507–14Knudsen, K Beckman Suurküla, M Blomberg, S Sjövall, J Edvarsson, N
Salonen MHA, Haasio J, Bachmann M, Xu M, Rosenberg PH: Evaluation of efficacy and plasma concentrations of ropivacaine in continuous axillary brachial plexus block: High dose for surgical anesthesia and low dose for post operative analgesia. Reg Anesth Pain Med 2000; 25: 47–51Salonen, MHA Haasio, J Bachmann, M Xu, M Rosenberg, PH
Behnke H, Worthmann F, Cornelissen J, Kahl M, Wulf H: Plasma concentration of ropivacaine after intercostal blocks for video-assisted thoracic surgery. Br J Anaesth 2002; 89: 251–3Behnke, H Worthmann, F Cornelissen, J Kahl, M Wulf, H
Ruetsch YA, Fattinger KE, Borgeat A: Ropivacaine-induced convulsions and severe cardiac dysrhythmia after sciatic block. A nesthesiology 1999; 90: 1784–6Ruetsch, YA Fattinger, KE Borgeat, A
van der Wal M, Lang SA, Yip RW: Transarterial approach for saphenous nerve block. Can J Anaesth 1993; 40: 542–6van der Wal, M Lang, SA Yip, RW
Sztark F, Malgat M, Dabadie P, Mazat JP: Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics. A nesthesiology 1998; 88: 1340–9Sztark, F Malgat, M Dabadie, P Mazat, JP
Graf BM, Abraham I, Eberbach N, Kunst G, Stowe DF, Martin E: Differences in cardiotoxicity of bupivacaine and ropivacaine are the results of physicochemical and stereoselective properties. A nesthesiology 2002; 96: 1427–34Graf, BM Abraham, I Eberbach, N Kunst, G Stowe, DF Martin, E
Plowman AN, Bolsin S, Mather LE: Central nervous system toxicity attributable to epidural ropivacaine hydrochloride. Anaesth Intensive Care 1998; 26: 204–6Plowman, AN Bolsin, S Mather, LE
Bischop DY, Alardo JP, Razgallah B, Just BY, Germain MLY, Millart HG, Trenque TC: Seizure induced by ropivacaine. Ann Pharmacother 2001; 35: 311–3Bischop, DY Alardo, JP Razgallah, B Just, BY Germain, MLY Millart, HG Trenque, TC
Mardirosoff C, Dumont L: Convulsions after the administration of high dose ropivacaine following an interscalenic block. Can J Anaesth 2000; 47: 1263Mardirosoff, C Dumont, L
Ala-Kokko TI, Löppönen A, Alahuhta S: Two instances of central nervous system toxicity in the same patient following repeated ropivacaine-induced brachial plexus block. Acta Anaesthesiol Scand 2000; 44: 623–6Ala-Kokko, TI Löppönen, A Alahuhta, S
Raeder JC, Drosdahl S, Klaastad O, Kvalsvik O, Isaksen B, Stromskag KE, Mowinckel P, Bergheim R, Selander D: Axillary brachial plexus block with ropivacaine 7.5 mg/ml: A comparative study with bupivacaine 5 mg/ml. Acta Anaesthesiol Scand 1999; 43: 794–8Raeder, JC Drosdahl, S Klaastad, O Kvalsvik, O Isaksen, B Stromskag, KE Mowinckel, P Bergheim, R Selander, D
Müller M, Litz RJ, Hübler M, Albrecht DM: Grand mal convulsion and plasma concentrations after intravascular injection of ropivacaine for axillary brachial plexus blockade. Br J Anaesth 2001; 87: 784–7Müller, M Litz, RJ Hübler, M Albrecht, DM
Ould-Ahmed M, Drouillard I, Fourel D, Roussaly P, Almanza L, Segalen F: Convulsions induites par la ropivacaïne lors d'un bloc au canal huméral. Ann Fr Anesth Reanim 2002; 21: 681–4Ould-Ahmed, M Drouillard, I Fourel, D Roussaly, P Almanza, L Segalen, F
Eledjam JJ, Gros T, Viel E, Mazoit JX, Bassoul B: Ropivacaine overdose and systemic toxicity. Anaesth Intensive Care 2000; 28: 705–7Eledjam, JJ Gros, T Viel, E Mazoit, JX Bassoul, B
Petitjeans F, Mion G, Puidupin M, Tourtier JP, Hutson C, Saïssy JM: Tachycardia and convulsions induced by accidental intravascular injection of ropivacaine during sciatic block. Acta Anaesthesiol Scand 2002; 46: 616–7Petitjeans, F Mion, G Puidupin, M Tourtier, JP Hutson, C Saïssy, JM
Mazoit JX: Toxicité des anesthésiques locaux, Conférences d'actualisation 2002, 44eCongrès national d'anesthésie réanimation. Edited by Sfar, Paris, Editions scientifiques et médicales Elsevier SAS, et Sfar, 2002, pp 287–301
Scott DB: Evaluation of the toxicity of local anesthetic agents in man. Br J Anaesth 1975; 47: 56–61Scott, DB
Periodic Safety Update Report: Naropin, AstraZeneca, May 17, 2000
Feldman HS, Arthur GR, Pitkanen M, Hurley R, Doucette AM, Covino BG: Treatment of acute systemic toxicity after the rapid venous injection of ropivacaine and bupivacaine in the conscious dog. Anesth Analg 1991; 73: 373–84Feldman, HS Arthur, GR Pitkanen, M Hurley, R Doucette, AM Covino, BG
Long WB, Rosenblum S, Grady IP: Successful resuscitation of bupivacaine induced cardiac arrest using cardiopulmonary bypass. Anesth Analg 1989; 69: 403–6Long, WB Rosenblum, S Grady, IP
Tsai MH, Tseng CK, Wong KC: Successful resuscitation of a bupivacaine-induced cardiac arrest using cardiopulmonary bypass and mitral valve replacement. J Cardiothorac Anesth 1987; 1: 454–6Tsai, MH Tseng, CK Wong, KC
Table 1. Previously Reported Cases of Severe Neurologic or Cardiac Adverse Effects Induced by Ropivacaine after Regional Anesthesia
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Table 1. Previously Reported Cases of Severe Neurologic or Cardiac Adverse Effects Induced by Ropivacaine after Regional Anesthesia