Free
Correspondence  |   October 2004
Postpartum Hemorrhage Is Not the Only Setting for Maternal Myocardial Ischemia
Author Notes
  • University of Arizona Health Sciences Center, Tucson, Arizona.
Article Information
Correspondence
Correspondence   |   October 2004
Postpartum Hemorrhage Is Not the Only Setting for Maternal Myocardial Ischemia
Anesthesiology 10 2004, Vol.101, 1036-1037. doi:
Anesthesiology 10 2004, Vol.101, 1036-1037. doi:
To the Editor:—
I read with great interest the article by Karpati et al.  1 documenting the high incidence of myocardial ischemia in parturients with significant postpartum hemorrhage. This is the second report that clearly documents the occurrence of myocardial ischemia in this population of young, otherwise healthy women with “normal” coronary arteries. In 2001, Moran et al.  2 used the newly available marker, myocardial troponin I, to definitively correlate electrocardiogram changes during cesarean section with myocardial ischemia. It is interesting to reflect how much views have changed during the past 15 yr.
In 1990, we published a series regarding the incidence of electrocardiographic changes during cesarean delivery.3 At that time, our hypothesis that parturients could experience ischemia solely on the basis of an imbalance of myocardial oxygen supply and demand was met with almost universal derision. Numerous other investigators subsequently confirmed a significant incidence of electrocardiographic changes,4–7 but of these, only Mathew et al.  4 conceded that myocardial ischemia might be a possible cause. There was tremendous resistance to the idea that ischemia could be induced in someone with “clean” coronary arteries, despite the fact that in every other setting, such electrocardiogram changes would be considered ischemia until proven otherwise. Almost any other explanation was considered more likely—neurocirculatory asthenia, vasoregulatory asthenia, hyperdynamic heart syndrome, mitral valve prolapse, autonomic system imbalance, cardiac sympathetic block, and epinephrine.4,7 
Now, Karpati et al.  1 can unabashedly state, “Our study … showed that myocardial ischemia was probably related to a significant alteration in the myocardial supply–demand ratio in parturients with otherwise ‘normal’ coronary arteries … myocardial oxygen supply was impaired by lowered arterial blood pressure, whereas increased heart rate resulted in an increased myocardial oxygen demand.” Not surprisingly, their findings of decreased blood pressure and increased heart rate mirror the findings in our 1990 series (table 5 in Palmer et al.  3).
Although it is nice to be have our original hypothesis validated after all these years, it also serves to prove the old adage: When you hear hoofbeats (in this case, chest pain, shortness of breath, and electrocardiogram changes), think horses, not zebras.
University of Arizona Health Sciences Center, Tucson, Arizona.
References
Karpati PCJ, Rossignol M, Pirot M, Cholley B, Vicaut E, Henry P, Kevorkian J, Schurando P, Peynet J, Jacob D, Payen D, Mebazaa A: High incidence of myocardial ischemia during postpartum hemorrhage. Anesthesiology 2004; 100:30–6Karpati, PCJ Rossignol, M Pirot, M Cholley, B Vicaut, E Henry, P Kevorkian, J Schurando, P Peynet, J Jacob, D Payen, D Mebazaa, A
Moran C, Ni Bhuinneain M, Geary M, Cunningham S, McKenna P, Gardiner J: Myocardial ischaemia in normal patients undergoing elective caesarean section: A peripartum assessment. Anaesthesia 2001; 56:1051–8Moran, C Ni Bhuinneain, M Geary, M Cunningham, S McKenna, P Gardiner, J
Palmer CM, Norris MC, Guidici MC, Leighton BL, DeSimone CA: Incidence of electrocardiographic changes during cesarean delivery under regional anesthesia. Anesth Analg 1990; 70:36–43Palmer, CM Norris, MC Guidici, MC Leighton, BL DeSimone, CA
Mathew JP, Fleisher LA, Rinehouse JA, Sevarino FB, Sinatra RS, Nelson AH, Prokop EK, Rosenbaum SH: ST segment depression during labor and delivery. Anesthesiology 1992; 77:635–41Mathew, JP Fleisher, LA Rinehouse, JA Sevarino, FB Sinatra, RS Nelson, AH Prokop, EK Rosenbaum, SH
Zakowski MI, Ramanathan S, Barratta JB, Cziner D, Goldstein MJ, Kronzon I, Turndorf H: Electrocardiographic changes during cesarean section: a cause for concern? Anesth Analg 1993; 76:162–7Zakowski, MI Ramanathan, S Barratta, JB Cziner, D Goldstein, MJ Kronzon, I Turndorf, H
McLintic AJ, Pringle SD, Lilley S, Houston AB, Thorburn J: Electrocardiographic changes during cesarean section under regional anesthesia. Anesth Analg 1992; 74:51–6McLintic, AJ Pringle, SD Lilley, S Houston, AB Thorburn, J
Eisenach JC, Tuttle R, Stein A: Is ST segment depression of the electrocardiogram during cesarean section merely due to cardiac sympathetic block? Anesth Analg 1994; 78:287–92Eisenach, JC Tuttle, R Stein, A