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Erratum  |   June 2012
Lidocaine Metabolites Inhibit Glycine Transporter 1: A Novel Mechanism for the Analgesic Action of Systemic Lidocaine?
Article Information
Erratum
Erratum   |   June 2012
Lidocaine Metabolites Inhibit Glycine Transporter 1: A Novel Mechanism for the Analgesic Action of Systemic Lidocaine?
Anesthesiology 6 2012, Vol.116, 1404. doi:10.1097/ALN.0b013e31825c47e2
Anesthesiology 6 2012, Vol.116, 1404. doi:10.1097/ALN.0b013e31825c47e2
In the article on page 147 of the January 2012 issue, in the Conclusions section of the Abstract, the word “glycinexylidide” appeared instead of “N-ethylglycine” in two places. The Conclusions section of the Abstract should read as follows:
Conclusions:  Although lidocaine does not function directly on GlyT1, its metabolites MEGX and N-ethylglycine were shown to inhibit GlyT1-mediated glycine uptake by at least two different mechanisms. Whereas N-ethylglycine was demonstrated to be an alternative GlyT1 substrate, MEGX was shown to inhibit GlyT1 activity in both primary astrocytes and in GlyT1-expressing Xenopus laevis  oocytes at clinically relevant concentrations. These findings provide new insights into the possible mechanisms for the antinociceptive effect of systemic lidocaine.
The publisher regrets this error.
Reference
Reference
Werdehausen R, Kremer D, Brandenburger T, Schlösser L, Jadasz J, Küry P, Bauer I, Aragón C, Eulenburg V, Hermanns H: Lidocaine metabolites inhibit glycine transporter 1: A novel mechanism for the analgesic action of systemic lidocaine? ANESTHESIOLOGY 2012; 116:147–58