Correspondence  |   June 2012
Neurophysiologic Monitoring during Thoracoabdominal Aortic Aneurysm Surgery
Author Affiliations & Notes
  • Paul G. Loubser, M.B., Ch.B.
  • *University of Texas Medical School at Houston, Heart and Vascular Institute, Memorial Hermann – Texas Medical Center, Houston, Texas.
Article Information
Correspondence   |   June 2012
Neurophysiologic Monitoring during Thoracoabdominal Aortic Aneurysm Surgery
Anesthesiology 6 2012, Vol.116, 1397-1398. doi:10.1097/ALN.0b013e318253a04a
Anesthesiology 6 2012, Vol.116, 1397-1398. doi:10.1097/ALN.0b013e318253a04a
To the Editor: 
Vaughn et al.  are to be commended for their excellent educational case report on anesthesia for thoracoabdominal aortic aneurysm repair.1 However, there is one area that we believe merits clarification, because it does not bring “completeness” to a full discussion of the subject. In their report, they tend to minimize the relative value and utility of neurophysiologic monitoring during thoracoabdominal aortic aneurysm (TAAA) surgery, while citing a small sample of studies and citing “drawbacks and limitations for the use of somatosensory-evoked potentials (SSEPs) and motor-evoked potentials (MEPs).”1 One is immediately reminded of the debate on cerebrospinal fluid drainage that raged for many years. As early as 1988, Hollier's group had provided evidence of the neuroprotective action of cerebrospinal fluid drainage in canine studies.2,3 However, skepticism prevailed among surgeons for many years. Crawford himself was highly skeptical of the modality, stating in 1991, “Thus cerebrospinal fluid drainage as we used it, was not beneficial in preventing paraplegia.”4 But, only in 1994, when Safi et al.  demonstrated the association between cerebrospinal fluid drainage and reduced postoperative neurologic deficits in TAAA patients, did the surgical community relent.5 
Several published reports have identified neurophysiologic monitoring as highly useful in the prediction and amelioration of neurologic complications occurring after TAAA surgery. In a study of 233 patients undergoing TAAA surgery, in which paired SSEP and MEP monitoring was conducted, our group demonstrated that SSEPs and MEPs were highly correlated when intraoperative changes were irreversible.6 These irreversible changes were significantly associated with immediate neurologic deficits. In contrast, normal SSEP and MEP findings had a strong negative predictive value for neurologic deficits. These findings confirm the results of Shine at al.  ,7 who reported a negative predictive value of 96% for MEPs, in the absence of any changes for 20 min after aortic cross-clamp application. In a further refinement, our group examined 108 patients undergoing TAAA surgery, citing loss of SSEPs and MEPs, in 26% and 50% of patients, respectively. Active intraoperative measures, which included intercostal artery reattachment in 85% of patients and judicious management of distal aortic and cerebrospinal fluid pressure, produced a return of SSEPs in all patients and a return of MEPs in all but one patient, (who awoke with an immediate neurologic deficit).8 MEPs can be highly reactive to spinal cord perfusion, as reported by Koeppel et al.  , who demonstrated rapid temporal changes of MEP loss and recovery, with interruption and restoration of distal aortic perfusion.9 
Why do Vaughn et al.  1 and ostensibly other surgical groups not embrace neurophysiologic monitoring during TAAA surgery? Well, they require an experienced team of a surgeon, neurologist, anesthesiologist, and perfusionist to ensure that they are effective and accurate. Coselli and Tsai recently questioned the validity of MEPs, citing interference by anesthesia agents and other potential factors.10 Our experiential track record has been quite the opposite. Indeed, we limit our use of inhalation agents to approximately 0.5 minimum alveolar concentration, but this is not a novel technique in cardiac anesthesia. We have transitioned to the use of shorter acting muscle relaxants such as rocuronium and cisatracurium. However, in some instances, we have found it necessary to suppress MEPs with a small dose of muscle relaxant to minimize MEP interference of the SSEP signal. Because MEPs actually produce muscle contraction and subtle patient movement, electrode detachment can occur at any time during the procedure and must be detected rapidly by the neurophysiology technician.
What was not borne out in Vaughn's article was the synergy of effort that is needed when cortical sensory evoked potentials, and in particular, when MEPs degrade during TAAA surgery, consisting of improving distal aortic perfusion (perfusionist), reducing cerebrospinal fluid pressure (anesthesiologist), and intercostal artery reattachment (surgeon). Likened to the aviation industry's “Crew Resource Management,” the team caring for the TAAA patient must all work aggressively and rapidly in an attempt to reverse these changes and mitigate neurologic complications.11 Based on the lessons learned from cerebrospinal fluid drainage, and in the interest of patient safety, we should view neurophysiologic monitoring during TAAA surgery not as an obscure modality as Vaughn et al.  impugn,1 but as a “standard-of-care.”
Vaughn SB, Lemaire SA, Collard CD: Anesthetic considerations for thoracoabdominal aortic aneurysm surgery. ANESTHESIOLOGY 2011; 115:1093–102
Bower TC, Murray MJ, Gloviczki P, Yaksh TL, Hollier LH, Pairolero PC: Effects of thoracic aortic occlusion and cerebrospinal fluid drainage on regional spinal cord blood flow in dogs: Correlation with neurologic outcome. J Vasc Surg 1989; 9:135–44
McCullough JL, Hollier LH, Nugent M: Paraplegia after thoracic aortic occlusion: Influence of cerebrospinal fluid drainage. Experimental and early clinical results. J Vasc Surg 1988; 7:153–60
Crawford ES, Svensson LG, Hess KR, Shenaq SS, Coselli JS, Safi HJ, Mohindra PK, Rivera V: A prospective randomized study of cerebrospinal fluid drainage to prevent paraplegia after high-risk surgery on the thoracoabdominal aorta. J Vasc Surg 1991; 13:36–45; discussion 45–6
Safi HJ, Bartoli S, Hess KR, Shenaq SS, Viets JR, Butt GR, Sheinbaum R, Doerr HK, Maulsby R, Rivera VM: Neurologic deficit in patients at high risk with thoracoabdominal aortic aneurysms: The role of cerebral spinal fluid drainage and distal aortic perfusion. J Vasc Surg 1994; 20:434–43; discussion 442–3
Keyhani K, Miller CC 3rd, Estrera AL, Wegryn T, Sheinbaum R, Safi HJ: Analysis of motor and somatosensory evoked potentials during thoracic and thoracoabdominal aortic aneurysm repair. J Vasc Surg 2009; 49:36–41
Shine TS, Harrison BA, De Ruyter ML, Crook JE, Heckman M, Daube JR, Stapelfeldt WH, Cherry KJ, Gloviczki P, Bower TC, Murray MJ: Motor and somatosensory evoked potentials: Their role in predicting spinal cord ischemia in patients undergoing thoracoabdominal aortic aneurysm repair with regional lumbar epidural cooling. ANESTHESIOLOGY 2008; 108:580–7
Estrera AL, Sheinbaum R, Miller CC 3rd, Harrison R, Safi HJ: Neuromonitor-guided repair of thoracoabdominal aortic aneurysms. J Thorac Cardiovasc Surg 2010; 140:S131–5; discussion S142–6
Koeppel TA, Mess WH, Jacobs MJ: Motor evoked potentials in thoracoabdominal aortic surgery: PRO. Cardiol Clin 2010; 28:351–60
Coselli JS, Tsai PI: Motor evoked potentials in thoracoabdominal aortic surgery: CON. Cardiol Clin 2010; 28:361–8
Griffin FA, Haraden C: Patient safety and medical errors, Healthcare Quality Handbook, 2nd Edition. Edited by Ransom ER, Maulik SJ, Nash DB, Ranson SB. Chicago, Health Administration Press, 2011, pp 243–68