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Correspondence  |   November 2010
Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain: Isoflurane or Ischemia-Reperfusion?
Author Affiliations & Notes
  • Jean Xavier Mazoit, M.D., Ph.D.
    *
  • *Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Article Information
Correspondence
Correspondence   |   November 2010
Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain: Isoflurane or Ischemia-Reperfusion?
Anesthesiology 11 2010, Vol.113, 1245. doi:10.1097/ALN.0b013e3181f710a4
Anesthesiology 11 2010, Vol.113, 1245. doi:10.1097/ALN.0b013e3181f710a4
To the Editor:
We read with great interest the article by Brambrink and colleagues.1 We want to raise a major point concerning their methodology and the ensuing interpretation of their results. The authors did not measure blood pressure in either the control group or at baseline in the treated animals. If we speculate that mean arterial pressure (MAP) measured at recovery time in their infant monkeys reflects MAP at baseline, a 35% decrease in MAP occurred during the entire procedure (see table 1 in their article). In infant animals as in infant humans, loss of autoregulation in preserved organs such as the central nervous system may rapidly occur, even when blood pressure moderately decreases. In a previous study, we observed that spinal cord blood flow was markedly decreased by epidural lidocaine in infant rabbits compared with adults and that the decrease in blood flow was correlated with a decrease in MAP.2 Also, another study from our group performed in former premature infants showed that spinal anesthesia was accompanied by a decrease in cerebral blood flow parallel to the decrease in peripheral blood pressure.3 Then, it can not be ruled out that the neurodegeneration observed by the authors was simply related to the decrease in MAP observed during the 5-hour procedure.
*Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
References
Brambrink AM, Evers AS, Avidan MS, Farber NB, Smith DJ, Zhang X, Dissen GA, Creeley CE, Olney JW: Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology 2010; 112:834–41Brambrink, AM Evers, AS Avidan, MS Farber, NB Smith, DJ Zhang, X Dissen, GA Creeley, CE Olney, JW
Bouaziz H, Okubo N, Malinovsky JM, Benhamou D, Samii K, Mazoit JX: The age-related effects of epidural lidocaine, with and without epinephrine, on spinal cord blood flow in anesthetized rabbits. Anesth Analg 1999; 88:1302–7Bouaziz, H Okubo, N Malinovsky, JM Benhamou, D Samii, K Mazoit, JX
Bonnet MP, Larousse E, Asehnoune K, Benhamou D: Spinal anesthesia with bupivacaine decreases cerebral blood flow in former preterm infants. Anesth Analg 2004; 98:1280–3Bonnet, MP Larousse, E Asehnoune, K Benhamou, D