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Correspondence  |   March 2010
Implicit Memory Phenomena under Anesthesia Are Not Spurious
Author Notes
  • Emory University School of Medicine, Atlanta, Georgia.
Article Information
Correspondence
Correspondence   |   March 2010
Implicit Memory Phenomena under Anesthesia Are Not Spurious
Anesthesiology 3 2010, Vol.112, 764-765. doi:10.1097/ALN.0b013e3181cf3ffc
Anesthesiology 3 2010, Vol.112, 764-765. doi:10.1097/ALN.0b013e3181cf3ffc
To the Editor:
I read with great interest the article by Hadzidiakos et al  .1 in the August issue of Anesthesiology. These investigators conducted a study of memory function under anesthesia using the process dissociation procedure (PDP), a method that my colleagues and I have used in the same context in the past.2–4 In contrast to our studies, Hadzidiakos et al.  report no evidence of memory function in terms of word stem completion test performance, a discrepancy for which the authors provide plausible explanations such as the depth of anesthesia and midazolam premedication. However, notwithstanding their null finding, one of the PDP models—the original—produced parameters suggesting the presence of controlled (explicit) and automatic (implicit) memory processes. By extending the model to include guessing parameters, the authors go on to show that the original model produces faulty estimates and that other published results using the original model are faulty. That is, Hadzidiakos et al.  find no evidence of any memory processes in three of the four inspected studies when the extended measurement model is applied. They conclude that in these studies there was no contribution (i.e.  , evidence) of memory at all and that past findings are spurious.
I take issue with this conclusion for several reasons. Foremost, a model that generates discrepant parameters depending on its assumptions or underlying structure should not invalidate the behavioral findings it attempts to model. When significant differences are found in patients' postoperative behavioral responses to old material presented under anesthesia versus  new material not presented before, this difference is real and evidences memory for old material regardless of how the underlying process is labeled. Dismissing these behavioral observations ignores an overwhelming body of evidence in favor of implicit memory (“priming”) phenomena in the cognitive psychology and neurology literature and surely cannot have been the intent of Hadzidiakos et al  . Although their critique of the original PDP model may be warranted in that the modeling heavily depends on (controversial) assumptions and proper test instructions,5 the evidence for or against memory function under anesthesia is based on actual response data and not on models. In many of the anesthesia studies cited by Hadzidiakos et al.  , and many more, response tendencies demonstrated memory for material presented under anesthesia, and the quest for understanding this phenomenon continues.6 Therefore, it would be wrong to imply or believe that memory function under anesthesia is a spurious phenomenon. Second, the authors failed to include studies that used the extended PDP model and found evidence of automatic memory processes.2,7 Although one study may not have properly implemented the PDP methodology and produced skewed estimates as a result,5 another found robust evidence of implicit memory function under seemingly adequate levels of anesthesia based on patient response data and Bucher's PDP model.2 It is not clear why this evidence was disregarded.
I commend the authors on undertaking their study and welcome their critical examination of a popular yet tricky methodological approach but regret their simplified argument and failure to distinguish between modeled and actual reality.
Emory University School of Medicine, Atlanta, Georgia.
References
Hadzidiakos D, Horn D, Buchner A, Rehberg B: Analysis of memory formation during general anesthesia (propofol/remifentanil) for elective surgery using the process-dissociation procedure. Anesthesiology 2009; 111:293–301Hadzidiakos, D Horn, D Buchner, A Rehberg, B
Lubke GH, Kerssens C, Phaf RH, Sebel PS: Dependence of explicit and implicit memory on hypnotic state in trauma patients. Anesthesiology 1999; 90:670–80Lubke, GH Kerssens, C Phaf, RH Sebel, PS
Lubke GH, Sebel PS: Awareness and different forms of memory in trauma anaesthesia. Curr Opin Anaesthesiol 2000; 13:161–5Lubke, GH Sebel, PS
Kerssens C, Lubke GH, Klein J, van der Woerd A, Bonke B: Memory function during propofol and alfentanil anesthesia: Predictive value of individual differences. Anesthesiology 2002; 97:382–9Kerssens, C Lubke, GH Klein, J van der Woerd, A Bonke, B
Kerssens C: Using the process dissociation procedure: the meaning and value of comparable base rates. Anesthesiology 2007; 107:172–3Kerssens, C
Kerssens C, Gaither JR, Sebel PS: Preserved memory function during bispectral index-guided anesthesia with sevoflurane for major orthopedic surgery. Anesthesiology 2009; 111:518–24Kerssens, C Gaither, JR Sebel, PS
Stonell CA, Leslie K, He C, Lee L: No sex differences in memory formation during general anesthesia. Anesthesiology 2006; 105:920–6Stonell, CA Leslie, K He, C Lee, L