Correspondence  |   October 2009
Esmolol May Abolish Volatile Anesthetic-induced Postconditioning by Scavenging Reactive Oxygen Species
Author Affiliations & Notes
  • Markus Lange, M.D.
  • *Klinikum der Bayerischen Julius-Maximilians-Universität, Würzburg, Germany. (Lange, Riess)
Article Information
Correspondence   |   October 2009
Esmolol May Abolish Volatile Anesthetic-induced Postconditioning by Scavenging Reactive Oxygen Species
Anesthesiology 10 2009, Vol.111, 925. doi:10.1097/ALN.0b013e3181b6548b
Anesthesiology 10 2009, Vol.111, 925. doi:10.1097/ALN.0b013e3181b6548b
In Reply:—
We thank Drs. Xia and Irwin for their interest in our study on the role of β-adrenergic signaling in anesthetic postconditioning1 and in the accompanying editorial view.2 We agree with Drs. Xia and Irwin that, besides their energy-sparing effect, several alternative mechanisms of β blockers might be responsible for their infarct size–reducing capacity. Apart from their effect on the interaction between β receptor activation and reactive oxygen species production3 and scavenging,4 β blockers can inhibit calcium/calmodulin -dependent protein kinase II5 and phospholipase A,6 exert membrane stabilizing effects,7 and may even have direct effects on mitochondrial electron transport and reactive oxygen species production.8 The role of alternative mechanisms is certainly supported by the finding that infarct size reduction by β blockade is independent of heart rate, the main determinant of myocardial oxygen consumption.9 It is entirely conceivable that the combination of different cardioprotective principles at different time points during reperfusion might provide additive protective effects. In this context, it is of interest that calcium/calmodulin -dependent protein kinase II is necessary for desflurane-induced postconditioning, whereas prolonged postischemic calcium/calmodulin -dependent protein kinase II blockade might attenuate adverse effects of ischemia/reperfusion injury, including remodeling.10 Thus, it might be reasonable to apply anesthetic postconditioning at the onset of reperfusion and to initiate β blockade later during reperfusion. However, further basic research and clinical studies will be necessary to determine an optimized cardioprotective approach and to identify the possible clinical consequences of these experimental findings.
The rabbits used in this study were between 8 and 12 weeks of age and weighed between 2.5 and 3.0 kg. Although cardioprotection by ischemic11 and pharmacological12 preconditioning can be attenuated or lost in senescent hearts, there is some evidence of preserved ischemic postconditioning in the aged myocardium.13 Thus, the impact of aging on the cardioprotective effects of β blockade, anesthetic postconditioning and their interaction with reactive oxygen species needs to be determined in future studies.
*Klinikum der Bayerischen Julius-Maximilians-Universität, Würzburg, Germany.
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