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Correspondence  |   October 2009
Ventilator-associated Pneumonia or Endotracheal Tube-associated Pneumonia or None of the Above? Lessons Learned from Laboratory Animal Studies
Author Affiliations & Notes
  • Lorenzo Berra, M.D.
    *
  • *Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. (Berra, Kolobow)
Article Information
Correspondence
Correspondence   |   October 2009
Ventilator-associated Pneumonia or Endotracheal Tube-associated Pneumonia or None of the Above? Lessons Learned from Laboratory Animal Studies
Anesthesiology 10 2009, Vol.111, 921-922. doi:10.1097/ALN.0b013e3181b64ae8
Anesthesiology 10 2009, Vol.111, 921-922. doi:10.1097/ALN.0b013e3181b64ae8
To the Editor:—
We wish to address the now almost universally accepted notion, well summarized in a recent manuscript “Ventilator-associated Pneumonia or Endotracheal Tube-associated Pneumonia: An Approach to the Pathogenesis and Preventive Strategies Emphasizing the Importance of the Endotracheal Tube” by Pneumatikos et al.  1 
The authors emphasize that “The accumulation of contaminated secretions from oropharynx or gastrointestinal tract in the subglottic space is a crucial event in the pathogenesis of VAP [ventilator-associated pneumonia].” Hence, the authors’ center of attention is directed to the pooled secretions around the cuff; they believe that “an important preventive strategy should focus on blocking up the leakage of subglottic secretions around the cuff (between ETT [endotrachial tube] and tracheal mucosa), drainage of secretions from subglottic space, and decontamination of the subglottic secretions;” while patient position has no impact on the incidence of ventilator-associated pneumonia, as it is not even mentioned, or alluded to.
Indeed, we have shown it is the patient position that is the sine qua non  factor that determines the probability (yes, even certainty) of whether bacteria colonized oropharyngeal (or subglottic) contents and tracheal/lung secretions, will gravitate towards the oropharynx, and back into the lungs, with important consequences for the patient (analogous to the waste-water tubing in the sewer line). The authors are kind to cite our study in sheep, using the Mucus Shaver and Mucus Slurper which, when combined with keeping the orientation of the trachea below horizontal, prevented accumulation of secretions within the lumen of the endotracheal tube, the trachea, and the lungs, without need for conventional tracheal suction. Left unsaid, our subsequent studies showed that tilting/keeping the trachea (and sheep) below horizontal alone resulted in equally good outcome: No pneumonia, and no lung bacterial colonization.2,3 
It is the latter observation that has consumed, over many years, most of our subsequent attention. Insufflating small tantalum discs into the trachea of sheep, beyond the tip of the endotracheal tube, has allowed us to monitor transport of so insufflated tantalum discs across and beyond the tip of the endotracheal tube and observe its travel during the course of mechanical ventilation. The results were as follows: With the sheep’s body/head oriented in the semirecumbent position, mucus-tracheal contents rather rapidly gravitate towards the lungs, then enter the mainstem bronchi, and lodge at the most distal end of the bronchi.4 
However, with the head/neck oriented horizontally/below horizontal (about 5–15 degrees), all mucus and secretions, together with the insufflated tantalum discs, exited the bronchi and the trachea, then entered the endotracheal tube, and then exited into the expiratory line water trap and not into the lungs.
In a recent prospective controlled trial, 80 intubated infants were randomized to supine position (n = 30) or to lateral position (n = 30) to keep the orientation of the neck/trachea at or below horizontal.5 After 5 days of mechanical ventilation, tracheal cultures were positive in 26 infants (87%) in the supine position group and in 9 infants (30%) in the lateral group (P  < 0.05). In the adult patient population, similar results have been observed (unpublished observations, Lorenzo Berra, M.D., Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, June 2009), showing feasibility of such patient management and excellent clinical outcome.
In summary, while medical devices (Mucus Shaver, Mucus Slurper, antiseptic impregnated endotracheal tubes, Hi-Lo Evac endotracheal tubes [Tyco Healthcare UK Ltd., Gosport, United Kingdom], prototype endotracheal tube cuff, and so forth) may represent an improvement in the care of the intubated and mechanically ventilated patient, we believe that the sole factor that can avoid pneumonia in our intubated patients is keeping the orientation of the endotracheal tube below horizontal to drain outward oropharyngeal bacteria–colonized secretions that travel according to the laws of gravity.
*Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
References
Pneumatikos IA, Dragoumanis CK, Bouros DE: Ventilator-associated pneumonia or endotracheal tube-associated pneumonia? An approach to the pathogenesis and preventive strategies emphasizing the importance of endotracheal tube. Anesthesiology 2009; 110:673–80Pneumatikos, IA Dragoumanis, CK Bouros, DE
Berra L, Curto F, Li Bassi G, Laquerriere P, Baccarelli A, Kolobow T: Antibacterial-coated tracheal tubes cleaned with the Mucus Shaver: A novel method to retain long-term bactericidal activity of coated tracheal tubes. Intensive Care Med 2006; 32:888–93Berra, L Curto, F Li Bassi, G Laquerriere, P Baccarelli, A Kolobow, T
Panigada M, Berra L, Greco G, Stylianou M, Kolobow T: Bacterial colonization of the respiratory tract following tracheal intubation-effect of gravity: An experimental study. Crit Care Med 2003; 31:729–37Panigada, M Berra, L Greco, G Stylianou, M Kolobow, T
Bassi GL, Zanella A, Cressoni M, Stylianou M, Kolobow T: Following tracheal intubation, mucus flow is reversed in the semirecumbent position: Possible role in the pathogenesis of ventilator-associated pneumonia. Crit Care Med 2008; 36:518–25Bassi, GL Zanella, A Cressoni, M Stylianou, M Kolobow, T
Aly H, Badawy M, El-Kholy A, Nabil R, Mohamed A: Randomized, controlled trial on tracheal colonization of ventilated infants: Can gravity prevent ventilator-associated pneumonia? Pediatrics 2008; 122:770–4Aly, H Badawy, M El-Kholy, A Nabil, R Mohamed, A