Free
Correspondence  |   April 2011
Muscle Relaxants and Electroencephalogram
Author Notes
  • Mount Sinai Medical Center, New York, New York.
Article Information
Correspondence
Correspondence   |   April 2011
Muscle Relaxants and Electroencephalogram
Anesthesiology 4 2011, Vol.114, 1001. doi:10.1097/ALN.0b013e31820fc9f7
Anesthesiology 4 2011, Vol.114, 1001. doi:10.1097/ALN.0b013e31820fc9f7
To the Editor:
I was surprised to read in the report of Ueyama et al.  1 the erroneous statement, “A muscle relaxant itself does not have an effect on electroencephalogram.” We described an increase in duration of electroencephalography isoelectric interval during burst suppression after the administration of pancuronium in dogs anesthetized with isoflurane.2 This effect was then reversed by antagonism of neuromuscular blockade with neostigmine. The failure of Ueyama et al.  1 to control for neuromuscular blockade in their study of pregnant patients may present a confounding variable.
Mount Sinai Medical Center, New York, New York.
References
Ueyama H, Hagihira S, Takashina M, Nakae A, Mashimo T: Pregnancy does not enhance volatile anesthetic sensitivity on the brain: An electroencephalographic analysis study. Anesthesiology 2010; 113:577–84Ueyama, H Hagihira, S Takashina, M Nakae, A Mashimo, T
Schwartz AE, Navedo AT, Berman MF: Pancuronium increases the duration of electroencephalogram burst suppression in dogs anesthetized with isoflurane. Anesthesiology 1992; 77:686–90Schwartz, AE Navedo, AT Berman, MF