Correspondence  |   June 2013
Closing the Loop on Relaxant Reversal
Author Affiliations & Notes
  • Lawrence J. Caruso, M.D.
    University of Florida College of Medicine, Gainesville, Florida.
  • David A. Paulus, M.D., M.S.
  • (Accepted for publication February 26, 2013.)
    (Accepted for publication February 26, 2013.)×
Article Information
Correspondence   |   June 2013
Closing the Loop on Relaxant Reversal
Anesthesiology 06 2013, Vol.118, 1482. doi:10.1097/ALN.0b013e31828fc802
Anesthesiology 06 2013, Vol.118, 1482. doi:10.1097/ALN.0b013e31828fc802
To the Editor:
We read with interest the article by Thilen et al.1  pertaining to residual paralysis. We commend the authors for clarifying the pitfalls of monitoring the periorbital muscles as opposed to the adductor pollicis muscle. However, we are curious as to how adequate reversal of neuromuscular blockade was assessed prior to extubation. Depending on the density of the block, complete reversal after an intermediate duration neuromuscular blocker may be rapid, but could take up to roughly 50min.2  Due to the variability and the danger of respiratory complications with residual paralysis, we consider it essential to document that adequate reversal has in fact occurred. As Plaud et al.3  highlight in their excellent review article, subjective assessment of train-of-four strength and measurement of tidal volume, two often mentioned parameters, are wholly inadequate to assess adequate reversal. Without quantitative train-of-four monitoring intraoperatively, 5 s head lift and sustained tetanus with 100 Hz are the best available parameters, although even these are not completely adequate. We question which measures were used in this study.
The authors state that the time interval from neostigmine administration to train-of-four ratio measurement was not significantly different between the two groups. Given the different degrees of neuromuscular blockade at the time of reversal (based on similar train-of-four at the two different sites), it is possible that the decision to extubate was based on time elapsed from neostigmine administration rather than specific measures of strength. The time pressure of getting patients extubated as well as reliance on less reliable measures such as tidal volume may explain this finding. While most patients will not be harmed (as shown in this study) by extubating with a train-of-four ratio less than 90, these patients are likely at increased risk of respiratory complications.4  As such, we encourage practitioners to confirm that the reversal drug has had the desired effect. To not do so makes an assumption which will be incorrect in a small but real percentage of patients.
Lawrence J. Caruso, M.D.,* David A. Paulus, M.D., M.S.† *University of Florida College of Medicine, Gainesville, Florida. †Deceased.
Thilen, SR, Hansen, BE, Ramaiah, R, Kent, CD, Treggiari, MM, Bhananker, SM Intraoperative neuromuscular monitoring site and residual paralysis.. Anesthesiology. (2012). 117 964–72 [Article] [PubMed]
Bevan, JC, Collins, L, Fowler, C, Kahwaji, R, Rosen, HD, Smith, MF, de Scheepers, LD, Stephenson, CA, Bevan, DR Early and late reversal of rocuronium and vecuronium with neostigmine in adults and children.. Anesth Analg. (1999). 89 333–9 [PubMed]
Plaud, B, Debaene, B, Donati, F, Marty, J Residual paralysis after emergence from anesthesia.. Anesthesiology. (2010). 112 1013–22 [Article] [PubMed]
Murphy, GS, Szokol, JW, Marymont, JH, Greenberg, SB, Avram, MJ, Vender, JS Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit.. Anesth Analg. (2008). 107 130–7 [Article] [PubMed]